Publication:
Assessing the feasibility of time in tight range (TITR) targets with advanced hybrid closed loop (AHCL) use in children and adolescents: a single-centre real-world study

dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGökçe, Tuğba
dc.contributor.kuauthorEviz, Elif
dc.contributor.kuauthorKarakuş, Kağan Ege
dc.contributor.kuauthorKıllı, Nesrin Ecem
dc.contributor.kuauthorCan, Ecem
dc.contributor.kuauthorHatun, Şükrü
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:30:56Z
dc.date.issued2024
dc.description.abstractAims: Time in Tight Range (TITR) is a novel glycaemic metric in monitoring type 1 diabetes (T1D) management. The aim of this study was to assess the attainability of the TITR target in children and adolescents using the advanced hybrid closed loop (AHCL). Methods: The 2128-day CGM data from 56 children and adolescents with T1D using AHCL (Minimed-780G) were analysed. Time in Range (TIR) (3.9-10 mmol/L), TITR (3.9-7.7 mmol/L), and other glycaemic parameters were separately analysed in terms of whole day, daytime (06.00-23:59), and nighttime (00.00-05.59) results. The participants were divided into two groups by autocorrection rate where Group 1 had a rate of <30% and Group 2 had a rate of >= 30. Results: All glycaemic parameters indicated a better glycaemic outcome in the nighttime with higher TIR and TITR values compared with daytime (for TIR 87.5 +/- 9.5% vs. 78.8 +/- 8%, p < 0.001, and TITR 68.2 +/- 13.5% vs. 57.5 +/- 8.8%, p < 0.001). The rates of TITR >50% and >60% were 87% and 52%, respectively. When those with TITR >60% (n: 29) and those without (n: 27) were evaluated in terms of hypoglycaemia, no statistically significant difference was found in time below range (TBR) 3-3.9 mmol/L (0.3% vs. 2.1%, p: 0.084) and TBR < 3 mmol/L (0.47% vs. 0.3%, p: 0.298). Group 1 had a significantly higher TIR and TITR compared to Group 2 (82.6 +/- 6.1% vs. 75.6 +/- 8.6%, p: 0.008 and 62.1 +/- 7.5% vs. 53.8 +/- 7.5%, p: 0.002, respectively). Conclusions: Most children and adolescents on AHCL achieved the 50% target for TITR whereas more than half achieved the >60% target. A target of >50% for TITR seems realistic in children with T1D using AHCL.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue8
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume41
dc.identifier.doi10.1111/dme.15333
dc.identifier.eissn1464-5491
dc.identifier.issn0742-3071
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85191715201
dc.identifier.urihttps://doi.org/10.1111/dme.15333
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26152
dc.identifier.wos1208669400001
dc.keywordsAdvanced hybrid closed loop
dc.keywordsTime in range
dc.keywordsTime in tight range
dc.keywordsType 1 diabetes
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofDiabetic Medicine
dc.subjectEndocrinology and metabolism
dc.titleAssessing the feasibility of time in tight range (TITR) targets with advanced hybrid closed loop (AHCL) use in children and adolescents: a single-centre real-world study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorEviz, Elif
local.contributor.kuauthorKarakuş, Kağan Ege
local.contributor.kuauthorMutlu, Rahime Gül Yeşiltepe
local.contributor.kuauthorCan, Ecem
local.contributor.kuauthorGökçe, Tuğba
local.contributor.kuauthorHatun, Şükrü
local.contributor.kuauthorKıllı, Nesrin Ecem
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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