Publication: Assessing the feasibility of time in tight range (TITR) targets with advanced hybrid closed loop (AHCL) use in children and adolescents: a single-centre real-world study
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Gökçe, Tuğba | |
dc.contributor.kuauthor | Eviz, Elif | |
dc.contributor.kuauthor | Karakuş, Kağan Ege | |
dc.contributor.kuauthor | Kıllı, Nesrin Ecem | |
dc.contributor.kuauthor | Can, Ecem | |
dc.contributor.kuauthor | Hatun, Şükrü | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2025-01-19T10:30:56Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Aims: Time in Tight Range (TITR) is a novel glycaemic metric in monitoring type 1 diabetes (T1D) management. The aim of this study was to assess the attainability of the TITR target in children and adolescents using the advanced hybrid closed loop (AHCL). Methods: The 2128-day CGM data from 56 children and adolescents with T1D using AHCL (Minimed-780G) were analysed. Time in Range (TIR) (3.9-10 mmol/L), TITR (3.9-7.7 mmol/L), and other glycaemic parameters were separately analysed in terms of whole day, daytime (06.00-23:59), and nighttime (00.00-05.59) results. The participants were divided into two groups by autocorrection rate where Group 1 had a rate of <30% and Group 2 had a rate of >= 30. Results: All glycaemic parameters indicated a better glycaemic outcome in the nighttime with higher TIR and TITR values compared with daytime (for TIR 87.5 +/- 9.5% vs. 78.8 +/- 8%, p < 0.001, and TITR 68.2 +/- 13.5% vs. 57.5 +/- 8.8%, p < 0.001). The rates of TITR >50% and >60% were 87% and 52%, respectively. When those with TITR >60% (n: 29) and those without (n: 27) were evaluated in terms of hypoglycaemia, no statistically significant difference was found in time below range (TBR) 3-3.9 mmol/L (0.3% vs. 2.1%, p: 0.084) and TBR < 3 mmol/L (0.47% vs. 0.3%, p: 0.298). Group 1 had a significantly higher TIR and TITR compared to Group 2 (82.6 +/- 6.1% vs. 75.6 +/- 8.6%, p: 0.008 and 62.1 +/- 7.5% vs. 53.8 +/- 7.5%, p: 0.002, respectively). Conclusions: Most children and adolescents on AHCL achieved the 50% target for TITR whereas more than half achieved the >60% target. A target of >50% for TITR seems realistic in children with T1D using AHCL. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 8 | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 41 | |
dc.identifier.doi | 10.1111/dme.15333 | |
dc.identifier.eissn | 1464-5491 | |
dc.identifier.issn | 0742-3071 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85191715201 | |
dc.identifier.uri | https://doi.org/10.1111/dme.15333 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/26152 | |
dc.identifier.wos | 1208669400001 | |
dc.keywords | Advanced hybrid closed loop | |
dc.keywords | Time in range | |
dc.keywords | Time in tight range | |
dc.keywords | Type 1 diabetes | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | Diabetic Medicine | |
dc.subject | Endocrinology and metabolism | |
dc.title | Assessing the feasibility of time in tight range (TITR) targets with advanced hybrid closed loop (AHCL) use in children and adolescents: a single-centre real-world study | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Eviz, Elif | |
local.contributor.kuauthor | Karakuş, Kağan Ege | |
local.contributor.kuauthor | Mutlu, Rahime Gül Yeşiltepe | |
local.contributor.kuauthor | Can, Ecem | |
local.contributor.kuauthor | Gökçe, Tuğba | |
local.contributor.kuauthor | Hatun, Şükrü | |
local.contributor.kuauthor | Kıllı, Nesrin Ecem | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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