Publication:
Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae

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dc.contributor.departmentDepartment of Molecular Biology and Genetics
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorDunn, Cory David
dc.contributor.kuauthorGaripler, Görkem
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2024-11-09T23:53:20Z
dc.date.issued2013
dc.description.abstractWhile searching for mutations that alleviate detrimental effects of mitochondrial DNA (mtDNA) damage, we found that disrupting vacuolar biogenesis permitted survival of a sensitized yeast background after mitochondrial genome loss. Furthermore, elevating vacuolar pH increases proliferation after mtDNA deletion and reverses the protein import defect of mitochondria lacking DNA.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipNational Institutes of Health [T32GM07445] We thank Hiromi Sesaki, Gulayse Ince Dunn, Nurhan Ozlu, Halil Kavakli, and Nebibe Mutlu for review of this manuscript. Special thanks to Rob Jensen at Johns Hopkins School of Medicine, in whose laboratory suppressors of the petite-negative phenotype were isolated using funds from a National Institutes of Health predoctoral training grant (T32GM07445) to C.D.D. Further support for this work was provided by Koc University's College of Sciences and by a European Molecular Biology Organization Installation grant to C.D.D.
dc.description.volume194
dc.identifier.doi10.1534/genetics.113.149708
dc.identifier.issn0016-6731
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-84877098900
dc.identifier.urihttps://doi.org/10.1534/genetics.113.149708
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14997
dc.identifier.wos318274900028
dc.keywordsSlow-growth phenotype
dc.keywordsAaa protease complex
dc.keywordsYeast-cells
dc.keywordsFunctional mitochondria
dc.keywordsPetite mutation
dc.keywordsLife-span
dc.keywordsAtpase
dc.keywordsMembrane
dc.keywordsProteins
dc.keywordsSubunit
dc.language.isoeng
dc.publisherGenetics Soc Am
dc.relation.ispartofGenetics
dc.subjectGenetics
dc.subjectHeredity
dc.titleDefects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGaripler, Görkem
local.contributor.kuauthorDunn, Cory David
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Sciences
local.publication.orgunit2Department of Molecular Biology and Genetics
local.publication.orgunit2Graduate School of Sciences and Engineering
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