Publication:
The role of the size and number of index lesion in the diagnosis of clinically significant prostate cancer in patients with PI-RADS 4 lesions detected by multiparametric MRI of the prostate.

dc.contributor.coauthorKılıç, Mert
dc.contributor.coauthorMadendere, Serdar
dc.contributor.coauthorVural, Metin
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBalbay, Mevlana Derya
dc.contributor.kuauthorEsen, Tarık
dc.contributor.kuauthorKöseoğlu, Ersin
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:38:21Z
dc.date.issued2023
dc.description.abstractPurpose: To evaluate the contribution of the size and number of the sampled lesions to the diagnosis of clinically significant prostate cancer (CSPC) in patients who had PI-RADS 4 lesions. Methods: In this retrospective study, a total of 159 patients who had PI-RADS 4 lesions and underwent In-bore MRI-Guided prostate biopsy were included. Patients with a lesion classified as Grade Group 2 and above were considered to have CSPC. Univariate and multivariate regression analyses were used to evaluate the factors affecting the diagnosis of prostate cancer (PCa) and CSPC. Results: A great majority (86.8%) of the patients were biopsy-naïve. About three-fourths (71.7%) had PCa, and half (54.1%) had CSPC. When the patients were divided into three groups according to the index lesion size (< 5 mm, 5-10 mm, and > 10 mm), the prevalence of PCa was 64.3, 67.5, and 82.4% and the prevalence of CSPC was 42.9, 51.2, and 64.7%, respectively. In multivariate analysis, age, index lesion size, prostate volume (< 50 ml) and being biopsy-naïve were found significant for PCa, while age and prostate volume (< 50 ml) were significant for CSPC. Conclusion: The number of lesions was found to be insignificant in predicting PCa and CSPC. While the size of PI-RADS 4 lesions was significant in predicting PCa, it had no significance in detecting CSPC.
dc.description.indexedbyWOS
dc.description.issueSupplement 6
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume41
dc.identifier.doi10.1200/JCO.2023.41.6_suppl.44
dc.identifier.eissn1527-7755
dc.identifier.issn0732-183X
dc.identifier.quartileQ1
dc.identifier.urihttps://doi.org/10.1200/JCO.2023.41.6_suppl.44
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22667
dc.identifier.wos1098050200132
dc.keywordsBiopsy
dc.keywordsMagnetic resonance imaging
dc.keywordsProstate cancer
dc.keywordsProstate imaging reporting and data system
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Clinical Oncology
dc.subjectOncology
dc.titleThe role of the size and number of index lesion in the diagnosis of clinically significant prostate cancer in patients with PI-RADS 4 lesions detected by multiparametric MRI of the prostate.
dc.typeMeeting Abstract
dspace.entity.typePublication
local.contributor.kuauthorKöseoğlu, Ersin
local.contributor.kuauthorBalbay, Mevlana Derya
local.contributor.kuauthorEsen, Tarık
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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