Publication:
A systematic review of safety and adverse effects in the practice of therapeutic hypothermia

dc.contributor.coauthorKarcioglu, Ozgur
dc.contributor.coauthorTopacoglu, Hakan
dc.contributor.coauthorDikme, Özgür
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorDikme, Özlem
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:52:02Z
dc.date.issued2018
dc.description.abstractObjective: To carry out a systematic review to estimate the rate and magnitude of adverse effects following therapeutic hypothermia (TH) procedure in patients resuscitated from out-of-hospital cardiac arrest (OHCA) and highlight the specific complications seen after the procedure. Methods: A systematic review of currently published studies was performed following standard guidelines. Online database searches were performed for controlled trials for the last twenty years. Papers were examined for methodological soundness before being included. Data were independently extracted by two blinded reviewers. Studies were also assessed for bias using the Cochrane criteria. The adverse effects attributed to TH in the literature were appraised critically. Results: The initial data search yielded 78 potentially relevant studies; of these, 59 were excluded for some reason. Themain reason for exclusion (n= 43, 55.8%) was that irrelevance to adverse effects of TH. Finally, 19 underwent full-text review. Studies were of high-to-moderate (n= 12, 63%) to low-to-very low (n= 7, 37%) quality. Five studies (27.7%) were found to have high risk of bias, while 8 (42.1%) had low risk of bias. Interpretation: Although adverse effects related to the practice of TH have been studied extensively, there is substantial heterogeneity between study populations and methodologies. There is a considerable incidence of side effects attributed to the procedure, e.g., from life-threatening ventricular arrhythmias to self-limited consequences. Most studies analyzed in this systematic review indicated that the procedure of TH has not caused severe adverse effects leading to significant alterations in the outcomes following resuscitation from OHCA. (C) 2018 Elsevier Inc. All rights reserved.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume36
dc.identifier.doi10.1016/j.ajem.2018.07.024
dc.identifier.eissn1532-8171
dc.identifier.issn0735-6757
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85049747678
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2018.07.024
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6954
dc.identifier.wos445001600031
dc.keywordsCardiac arrest
dc.keywordsTherapeutic hypothermia
dc.keywordsHypothermia
dc.keywordsAdverse effects
dc.keywordsSide effects
dc.keywordsTargeted temperature management
dc.keywordsOut-of-hospital cardiac arrest
dc.keywordsSystematic review hospital cardiac-arrest
dc.keywordsTargeted temperature management
dc.keywordsComatose survivors
dc.keywords33-Degrees-C
dc.keywordsStatement
dc.keywordsImprove
dc.keywordsEvents
dc.keywordsCare
dc.language.isoeng
dc.publisherW B Saunders Co-Elsevier Inc
dc.relation.ispartofAmerican Journal of Emergency Medicine
dc.subjectEmergency medicine
dc.titleA systematic review of safety and adverse effects in the practice of therapeutic hypothermia
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorDikme, Özlem
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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