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The role of uric acid in mineral bone disorders in chronic kidney disease

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dc.contributor.coauthorAfsar, Baris
dc.contributor.coauthorSag, Alan A.
dc.contributor.coauthorKuwabara, Masanari
dc.contributor.coauthorCozzolino, Mario
dc.contributor.coauthorCovic, Adrian
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorÖztosun, Çınar
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:09:29Z
dc.date.issued2019
dc.description.abstractIncreasing survival in the chronic kidney disease (CKD) population exposes the bone to the cumulative detrimental sequelae of CKD, now defined physiologically and histopathologically as chronic kidney disease mineral bone disorder (CKD-BMD). This disorder is increasingly recognized as a "nontraditional" driver of morbidity and mortality and presents an opportunity to improve CKD outcomes via research. However, recent advances in the literature on this topic have not yet been collected into a single review. Therefore, this report aims to discuss the disordered renal-bone axis in CKD-BMD, molecular and hormonal drivers, novel treatment strategies, and forthcoming research in a clinician-directed format. A key novel topic will be the unique impact of uric acid on CKD-BMD, which is poised to apply extensive existing research in the uric acid domain to benefit the CKD-BMD population.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume32
dc.identifier.doi10.1007/s40620-019-00615-0
dc.identifier.eissn1724-6059
dc.identifier.issn1121-8428
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85064934012
dc.identifier.urihttps://doi.org/10.1007/s40620-019-00615-0
dc.identifier.urihttps://hdl.handle.net/20.500.14288/17140
dc.identifier.wos487071400005
dc.keywordsUric acid
dc.keywordsMineral bone disorder
dc.keywordsFGF-23
dc.keywordsVitamin D
dc.keywordsParathyroid hormone
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Nephrology
dc.subjectUrology
dc.subjectNephrology
dc.titleThe role of uric acid in mineral bone disorders in chronic kidney disease
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorÖztosun, Çınar
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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