Publication:
Management and outcomes of gastrointestinal congenital anomalies in low, middle and high income countries: protocol for a multicentre, international, prospective cohort study

dc.contributor.coauthorWright, Naomi Jane
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAydın, Emrah
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:21:37Z
dc.date.issued2019
dc.description.abstractIntroduction: congenital anomalies are the fifth leading cause of death in children <5years of age globally, contributing an estimated half a million deaths per year. Very limited literature exists from low and middle income countries (LMICs) where most of these deaths occur. The Global PaedSurg Research Collaboration aims to undertake the first multicentre, international, prospective cohort study of a selection of common congenital anomalies comparing management and outcomes between low, middle and high income countries (HICs) globally. Methods and analysis: the Global PaedSurg Research Collaboration consists of surgeons, paediatricians, anaesthetists and allied healthcare professionals involved in the surgical care of children globally. Collaborators will prospectively collect observational data on consecutive patients presenting for the first time, with one of seven common congenital anomalies (oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation and Hirschsprung's disease). Patient recruitment will be for a minimum of 1month from October 2018 to April 2019 with a 30-day post-primary intervention follow-up period. Anonymous data will be collected on patient demographics, clinical status, interventions and outcomes using REDCap. Collaborators will complete a survey regarding the resources and facilities for neonatal and paediatric surgery at their centre. The primary outcome is all-cause in-hospital mortality. Secondary outcomes include the occurrence of post-operative complications. Chi-squared analysis will be used to compare mortality between LMICs and HICs. Multilevel, multivariate logistic regression analysis will be undertaken to identify patient-level and hospital-level factors affecting outcomes with adjustment for confounding factors. Ethics and dissemination: at the host centre, this study is classified as an audit not requiring ethical approval. All participating collaborators have gained local approval in accordance with their institutional ethical regulations. Collaborators will be encouraged to present the results locally, nationally and internationally. The results will be submitted for open access publication in a peer reviewed journal.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue8
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipNIHR Global Health Research Unit on Health System Strengthening in Sub-Saharan Africa, King's College London
dc.description.sponsorshipNational Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King's College Hospital NHS Foundation Trust
dc.description.sponsorshipKing's Health Partners (Guy's and St Thomas' NHS Foundation Trust, King's College Hospital NHS Foundation Trust, King's College London and South London and Maudsley NHS Foundation Trust
dc.description.sponsorshipGuy's and St Thomas' Charity
dc.description.sponsorshipMaudsley Charity
dc.description.sponsorshipHealth Foundation
dc.description.sponsorshipASPIRES research programme in LMICs (Antibiotic use across Surgical Pathways-Investigating, Redesigning and Evaluating Systems) - Economic and Social Research Council
dc.description.versionPublisher version
dc.description.volume9
dc.identifier.doi10.1136/bmjopen-2019-030452
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02007
dc.identifier.issn2044-6055
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85071769402
dc.identifier.urihttps://doi.org/10.1136/bmjopen-2019-030452
dc.identifier.wos502537200339
dc.keywordsPediatric surgery
dc.keywordsPediatric anaesthesia
dc.keywordsPediatric intensive and critical care
dc.keywordsNeonatology
dc.keywordsPediatrics
dc.keywordsNeonatal intensive and critical care
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.grantno203905/Z/16/Z
dc.relation.grantnoGHRU 16/136/54
dc.relation.ispartofBMJ Open
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8628
dc.subjectMedicine
dc.subjectPediatric surgery
dc.titleManagement and outcomes of gastrointestinal congenital anomalies in low, middle and high income countries: protocol for a multicentre, international, prospective cohort study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAydın, Emrah
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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