Publication:
Microsphere-based optical system for biosensor applications

dc.contributor.departmentDepartment of Electrical and Electronics Engineering
dc.contributor.departmentDepartment of Physics
dc.contributor.kuauthorBilici, Temel
dc.contributor.kuauthorİşçi, Şenol
dc.contributor.kuauthorKurt, Adnan
dc.contributor.kuauthorSerpengüzel, Ali
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.date.accessioned2024-11-09T12:25:27Z
dc.date.issued2004
dc.description.abstractOptical microsphere resonators have been recently utilized in quantum optics, laser science, spectroscopy, and optoelectronics and attracted increasing interest due to their unique optical properties. Microspheres possess high quality factor (Q-factor) optical morphology dependent resonances, and have relatively small volumes. High-Q morphology dependent resonances are very sensitive to the refractive index change and microsphere uniformity. These tiny optical cavities, whose diameters may vary from a few to several hundred micrometers, have resonances with reported Q-factors as large as 3 x 10(9). Due to their sensitivity, morphology dependent resonances of microspheres are also considered for biosensor applications. Binding of a protein or other biomolecules can be monitored by observing the wavelength shift of morphology dependent resonances. A biosensor, based on this optical phenomenon, can even detect a single molecule, depending on the quality of the system design. In this work, elastic scattering spectra from the microspheres of different materials are experimentally obtained and morphology dependent resonances are observed. Preliminary results of unspecific binding of biomolecules onto the microspheres are presented. Furthermore, the morphology dependent resonances of the microspheres for biosensor applications are analyzed theoretically both for proteins such as bovine serum albumin.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.identifier.doi10.1117/12.532159
dc.identifier.eissn1996-756X
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00693
dc.identifier.isbn0-8194-5225-4N608
dc.identifier.issn0277-786X
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-5644258507
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1589
dc.identifier.wos222939100024
dc.keywordsInstruments and instrumentation
dc.keywordsDielectric microsphere
dc.keywordsEvanescent coupling
dc.keywordsIntegrated optoelectronics
dc.keywordsMicrosphere resonator
dc.keywordsMorphology dependent resonances
dc.keywordsOptical biosensor
dc.keywordsOptical coupler
dc.keywordsOptical fiber
dc.keywordsOptical resonance
dc.keywordsWhispering gallery modes
dc.language.isoeng
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)
dc.relation.ispartofProceedings of SPIE
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/694
dc.subjectBiomedical engineering
dc.subjectOptics
dc.titleMicrosphere-based optical system for biosensor applications
dc.typeConference Proceeding
dspace.entity.typePublication
local.contributor.kuauthorİşçi, Şenol
local.contributor.kuauthorBilici, Temel
local.contributor.kuauthorSerpengüzel, Ali
local.contributor.kuauthorKurt, Adnan
local.publication.orgunit1College of Sciences
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Physics
local.publication.orgunit2Department of Electrical and Electronics Engineering
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relation.isOrgUnitOfPublicationc43d21f0-ae67-4f18-a338-bcaedd4b72a4
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