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Antitumor efficacy of ceranib-2 with nano-formulation of PEG and rosin esters

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dc.contributor.coauthorBen Taleb, Ali
dc.contributor.coauthorKarakuş, Selcan
dc.contributor.coauthorTan, Ezgi
dc.contributor.coauthorIlgar, Merve
dc.contributor.coauthorKutlu, Özlem
dc.contributor.coauthorKutlu, Hatice Mehtap
dc.contributor.coauthorKilislioğlu, Ayben
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.facultymemberYes
dc.contributor.kuauthorGözüaçık, Devrim
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:46:44Z
dc.date.issued2021
dc.description.abstractCeranib-2 is a recently discovered, poorly water-soluble potent ceramidase inhibitor, with the ability to suppress cancer cell proliferation and delay tumor growth. However, its poor water solubility and weak cellular bioavailability hinder its use as a therapeutic agent for cancer. PEGylated rosin esters are an excellent platform as a natural polymer for drug delivery applications, especially for controlling drug release due to their degradability, biocompatibility, capability to improve solubility, and pharmacokinetics of potent drugs. In this study, stable aqueous amphiphilic submicron-sized PEG400-rosin ester-ceranib-2 (PREC-2) particles, ranging between 100 and 350 nm in a 1:1 mixture, were successfully synthesized by solvent evaporation mediated by sonication. Conclusion: Stable aqueous PEGylated rosin ester nanocarriers might present a significant solution to improve solubility, pharmacokinetic, and bioavailability of ceranib-2, and hold promises for use as an anticancer adjacent drug after further investigations.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.peerreviewstatusN/A
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipThis work has been co-financed by the European Union and Greek national funds through the program “Support for Researchers with Emphasis on Young Researchers” (call code: EDBM34, ΚΕ 14995) and under the research title “Preparation and study of innovative forms of administration of pharmaceutical molecules targeting at improved pharmacological properties.”
dc.description.studentonlypublicationNo
dc.description.studentpublicationNo
dc.description.versionN/A
dc.identifier.WoSQuartileN/A
dc.identifier.doi10.1007/978-1-0716-0920-0_16
dc.identifier.eissn1940-6029
dc.identifier.embargoN/A
dc.identifier.endpage220
dc.identifier.grantnoEDBM34
dc.identifier.grantnoKE 14995
dc.identifier.isbn9781071609200
dc.identifier.isbn9781071609194
dc.identifier.isbn9781071609224
dc.identifier.issn1064-3745
dc.identifier.pubmed33113138
dc.identifier.scopus2-s2.0-85094836206
dc.identifier.startpage199
dc.identifier.urihttps://doi.org/10.1007/978-1-0716-0920-0_16
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14003
dc.identifier.volume2207
dc.identifier.wos000691010900017
dc.keywordsCeranib-2
dc.keywordsRosin ester
dc.keywordsPEGylation
dc.keywordsNanoencapsulation
dc.keywordsAnticancer
dc.language.isoeng
dc.publisherHumana Press
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofSupramolecules in Drug Discovery and Drug Delivery: Methods and Protocols
dc.relation.openaccessN/A
dc.rightsN/A
dc.subjectNanoparticle drug delivery for cancer therapy
dc.subjectCeranib-2 nano-formulation
dc.subjectPolymeric nanocarriers in anticancer drug delivery
dc.titleAntitumor efficacy of ceranib-2 with nano-formulation of PEG and rosin esters
dc.typeBook Chapter
dspace.entity.typePublication
local.contributor.kuauthorGözüaçık, Devrim
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relation.isGoalOfPublication.latestForDiscoverya9786601-9431-4553-9a46-013bb366fb87
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