Publication:
Multi-omic markers of Intraductal Papillary Mucinous Neoplasms progression into pancreatic cancer

dc.contributor.coauthorCorradi, Chiara
dc.contributor.coauthorGentiluomo, Manuel
dc.contributor.coauthorSainz, Juan
dc.contributor.coauthorCamisa, Paolo Riccardo
dc.contributor.coauthorWlodarczyk, Barbara
dc.contributor.coauthorCrippa, Stefano
dc.contributor.coauthorTavano, Francesca
dc.contributor.coauthorCapurso, Gabriele
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUISCID (Koç University İşbank Center for Infectious Diseases)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAdsay, Nazmi Volkan
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T21:00:29Z
dc.date.issued2024
dc.description.abstractPancreatic ductal adenocarcinoma (PDAC) is the most lethal and common form of pancreatic cancer, it has no specific symptoms, and most of the patients are diagnosed when the disease is already at an advanced stage. Chemotherapy typically has only a modest effect, making surgery the most effective treatment option. However, only a small percentage of patients are amenable to surgery. One viable strategy to reduce PDAC death burden associated with the disease is to focus on precursor lesions and identify markers able to predict who will evolve into PDAC. While most PDACs are believed to be preceded by pancreatic intraepithelial neoplasms (PanINs), 5-10 % arise from Intraductal papillary mucinous neoplasms (IPMNs), which are mass-forming cystic lesions that are very common in the general population. IPMNs offer an invaluable model of pancreatic carcinogenesis for researchers to analyse, as well as a target population for PDAC early detection by clinicians. The evolution of IPMN into cancer is a complex and multistep process, therefore the identification of individual markers will not be the solution. In recent years, multiple omics technologies have been instrumental to identify possible biomarkers of IPMN progression and carcinogenesis. The only foreseeable strategy will be to integrate multi-omics data, alongside clinical and morphological features, into a progression score or signature using either standard epidemiologic tools or artificial intelligence. The aim of this manuscript is to review the current knowledge on genetic biomarkers and to briefly mention also additional omics, such as metabolomics, the exposome, the miRNome and epigenomics of IPMNs.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1016/j.semcancer.2024.12.005
dc.identifier.eissn1096-3650
dc.identifier.issn1044-579X
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85213878407
dc.identifier.urihttps://doi.org/10.1016/j.semcancer.2024.12.005
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27899
dc.identifier.volume109
dc.identifier.wos1399067500001
dc.keywordsIntraductal papillary mucinous neoplasm
dc.keywordsPolymorphisms
dc.keywordsMicroRNA
dc.keywordsExposome
dc.keywordsMetabolomics
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofSeminars in Cancer Biology
dc.subjectOncology
dc.titleMulti-omic markers of Intraductal Papillary Mucinous Neoplasms progression into pancreatic cancer
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAdsay, Nazmi Volkan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUISCID (Koç University İşbank Center for Infectious Diseases)
local.publication.orgunit2School of Medicine
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