Publication:
Characterization of the vessel geometry, flow mechanics and wall shear stress in the great arteries of wildtype prenetal mouse

dc.contributor.coauthorYap, C. H.
dc.contributor.coauthorLiu, X.
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.kuauthorPekkan, Kerem
dc.contributor.kuprofileFaculty Member
dc.contributor.otherDepartment of Mechanical Engineering
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.yokid161845
dc.date.accessioned2024-11-09T12:45:09Z
dc.date.issued2014
dc.description.abstractIntroduction: Abnormal fluid mechanical environment in the pre-natal cardiovascular system is hypothesized to play a significant role in causing structural heart malformations. It is thus important to improve our understanding of the prenatal cardiovascular fluid mechanical environment at multiple developmental time-points and vascular morphologies. We present such a study on fetal great arteries on the wildtype mouse from embryonic day 14.5 (E14.5) to near-term (E18.5). Methods: Ultrasound bio-microscopy (UBM) was used to measure blood velocity of the great arteries. Subsequently, specimens were cryo-embedded and sectioned using episcopic fluorescent image capture (EFIC) to obtain high-resolution 2D serial image stacks, which were used for 3D reconstructions and quantitative measurement of great artery and aortic arch dimensions. EFIC and UBM data were input into subject-specific computational fluid dynamics (CFD) for modeling hemodynamics. Results: In normal mouse fetuses between E14.5-18.5, ultrasound imaging showed gradual but statistically significant increase in blood velocity in the aorta, pulmonary trunk (with the ductus arteriosus), and descending aorta. Measurement by EFIC imaging displayed a similar increase in cross sectional area of these vessels. However, CFD modeling showed great artery average wall shear stress and wall shear rate remain relatively constant with age and with vessel size, indicating that hemodynamic shear had a relative constancy over gestational period considered here. Conclusion: Our EFIC-UBM-CFD method allowed reasonably detailed characterization of fetal mouse vascular geometry and fluid mechanics. Our results suggest that a homeostatic mechanism for restoring vascular wall shear magnitudes may exist during normal embryonic development. We speculate that this mechanism regulates the growth of the great vessels.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume9
dc.formatpdf
dc.identifier.doi10.1371/journal.pone.0086878
dc.identifier.eissn1932-6203
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00160
dc.identifier.issn1932-6203
dc.identifier.linkhttps://doi.org/10.1371/journal.pone.0086878
dc.identifier.quartileQ2
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2430
dc.identifier.wos330507300112
dc.keywordsComputational fluid-dynamics
dc.keywordsCongenital heart-disease
dc.keywordsEndothelial-cells
dc.keywordsBlood-flow
dc.keywordsGene-expression
dc.keywordsOutflow tract
dc.keywordsPrimary
dc.keywordsCilia
dc.keywordsAortic-valve
dc.keywordsChick-embryo
dc.keywordsCurved pipe
dc.languageEnglish
dc.publisherPublic Library of Science
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/1191
dc.sourcePLOS One
dc.subjectMultidisciplinary sciences
dc.subjectScience and technology
dc.titleCharacterization of the vessel geometry, flow mechanics and wall shear stress in the great arteries of wildtype prenetal mouse
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0001-7637-4445
local.contributor.kuauthorPekkan, Kerem
relation.isOrgUnitOfPublicationba2836f3-206d-4724-918c-f598f0086a36
relation.isOrgUnitOfPublication.latestForDiscoveryba2836f3-206d-4724-918c-f598f0086a36

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
1191.pdf
Size:
1.9 MB
Format:
Adobe Portable Document Format