Publication:
Recent advances in Takayasu's arteritis

dc.contributor.coauthorAlibaz Öner, Fatma
dc.contributor.coauthorDireskeneli, Haner
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAydın, Sibel Zehra
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T11:47:06Z
dc.date.issued2015
dc.description.abstractTakayasu’s arteritis (TAK) is a rare, chronic large-vessel vasculitis (LVV) that predominantly affects the aorta, its major branches, and the pulmonary arteries. Recent advances in the diagnosis, clinical course, disease assessment with biomarkers/imaging and new clinical tools, patient-reported outcomes, and new treatment options of TAK are discussed in this review. Conventional angiography, the gold standard method for initial diagnosis, appears to have been replaced with new imaging modalities such as magnetic resonance angiography (MRA) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in recent years. MRA and FDG-PET are also promising for the assessment of disease activity. New tools for disease assessment such as Indian Takayasu’s Arteritis Score 2010 (ITAS2010) and color Doppler ultrasound (CDUS) aim to better characterize and quantify disease activity; however, different imaging modalities in routine follow-up are not incorporated sufficiently in these approaches. Prognosis is possibly getting better, with lower mortality in recent years; however, it is difficult to assess the widely different vascular intervention rates among the clinical series. Leflunomide, tumor necrosis factor (TNF)-α antagonists, and tocilizumab are new options for patients resistant to conventional therapies. There is a clear need to develop a validated set of outcome measures for use in clinical trials of TAK. The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group has taken on this task, finished a Delphi exercise with experts, and aims to develop a core set of outcomes for LVV in accordance with OMERACT Filter 2.0.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume2
dc.identifier.doi10.5152/eurjrheumatol.2015.0060
dc.identifier.eissn2148-4279
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00656
dc.identifier.issn2147-9720
dc.identifier.quartileN/A
dc.identifier.urihttps://hdl.handle.net/20.500.14288/554
dc.identifier.wos360384700006
dc.keywordsTakayasu’s arteritis
dc.keywordsDisease assessment
dc.keywordsOutcome
dc.language.isoeng
dc.publisherAves
dc.relation.ispartofEuropean Journal of Rheumatology
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/523
dc.subjectMedicine
dc.titleRecent advances in Takayasu's arteritis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAydın, Sibel Zehra
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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