Publication:
Initial neutrophil-to-lymphocyte ratio predicts radiation-induced trismus in parotid gland cancer

dc.contributor.coauthorSomay, Efsun
dc.contributor.coauthorYılmaz, Büşra
dc.contributor.coauthorTopkan, Erkan
dc.contributor.coauthorKüçük, Ahmet
dc.contributor.coauthorPehlivan, Berrin
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSelek, Uğur
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:47:16Z
dc.description.abstractObjective: To investigate the link between pretreatment neutrophil-to-lymphocyte ratio(NLR) and the incidence of radiation-induced trismus(RIT) in parotid gland cancers(PGC) patients after postoperative radiotherapy(PORT). Method: Data of PGC patients who had oral examinations before and after PORT were reviewed retrospectively. We comprised patients who had maximum mouth opening (MMO) assessments before and after PORT and complete blood count test on the first day of PORT. MMO of <= 35 mm was considered as RIT. The receiver operating characteristic (ROC) curve analysis was used to search for an ideal NLR threshold value that might be linked to RIT rates. Results: Fifty-one patients were included, with a RIT incidence of 15.7%. The NLR cutoff that showed a link with the prevalence of RIT in the ROC curve analysis was 2.7[Area under the curve (AUC):82.0%; sensitivity:87.5%; specificity:74.4%]. The patients were divided into groups based on this value:Group 1: NLR <= 2.7 (N = 34) and;NLR >2.7 (N = 17). In comparative analysis, the incidence of RIT was found to be statistically higher in the NLR >2.7 than counterpart (35.2%vs.5.8%;r(s):0.79; p < .001). Also, a mean temporomandibular joint dose >= 51.0Gy was linked to increased RIT rates (p < .001). Conclusion: This study showed that high pre-PORT NLR levels were a robust and independent predictor of significantly elevated rates of RIT.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1111/odi.14429
dc.identifier.eissn1601-0825
dc.identifier.issn1354-523X
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85142354401
dc.identifier.urihttps://doi.org/10.1111/odi.14429
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14088
dc.identifier.wos888457300001
dc.keywordsInflammation
dc.keywordsNeutrophil-to-lymphocyte ratio
dc.keywordsParotid gland cancers
dc.keywordsPostoperative radiotherapy
dc.keywordsTrismus temporomandibular-joint arthrocentesis
dc.keywordsNeutrophil/lymphocyte ratio
dc.keywordsRheumatoid-arthritis
dc.keywordsDisease-activity
dc.keywordsInflammation
dc.keywordsRadiotherapy
dc.keywordsHead
dc.keywordsAssociation
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofOral Diseases
dc.subjectDentistry
dc.subjectOral surgeons
dc.subjectMedicine
dc.titleInitial neutrophil-to-lymphocyte ratio predicts radiation-induced trismus in parotid gland cancer
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSelek, Uğur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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