Publication:
Endoscopic submucosal dissection of seborrheic keratosis-like lesion of the esophagus: a new entity?

dc.contributor.coauthorEkinci, Neşe
dc.contributor.coauthorGün, Eylül
dc.contributor.kuauthorAslan, Fatih
dc.contributor.kuprofileFaculty Member
dc.contributor.unitKoç University Hospital
dc.contributor.yokid219202
dc.date.accessioned2024-11-09T13:06:56Z
dc.date.issued2020
dc.description.abstractSeborrheic keratosis, one of the most common lesions of the epidermis, is rarely seen on mucosal surfaces. We report a case of a distinctive epithelial neoplasm of the esophagus showing close resemblance to seborrheic keratosis that was resected with endoscopic submucosal dissection. A 65-year-old patient's previous esophageal biopsy showed suspicious low grade dysplasia and the patient was referred for endoscopic submucosal dissection of a flat lesion in the mid-esophagus. Macroscopic examination revealed a well circumscribed, pigmented and elevated lesion with a diameter of 20 mm. Microscopically, the lesion was well circumscribed, with plaque-like elevation, and showed hyperkeratosis, acanthosis, and papillomatosis. Broad coalescing solid sheets and interconnecting trabeculae of basaloid cells were the consistent feature throughout the lesion. Squamous eddies and occasional central keratinization were present. Mitotic activity and koilocytes were not identified. Immunohistochemically, the lesion showed diffuse nuclear positivity with p63 and negativity with p16. Ki-67 index was confined to the basal cell layer. With the help of histopathologic and immunohistochemical findings, we diagnosed this morphologically benign case as "seborrheic keratosis-like lesion of the esophagus". It should be kept in mind that seborrheic keratosis-like lesions might be rarely seen on mucosal surfaces such as the esophagus. Endoscopic submucosal dissection is a new, curative, and safe endoscopic resection technique in en-bloc resection of superficial esophageal lesions. To our knowledge, this is the first case of the aforementioned lesion in the esophagus being resected with endoscopic submucosal dissection.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume36
dc.formatpdf
dc.identifier.doi10.5146/tjpath.2018.01447
dc.identifier.eissn1309-5730
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02082
dc.identifier.issn1018-5615
dc.identifier.linkhttps://doi.org/10.5146/tjpath.2018.01447
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85077376397
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2524
dc.identifier.wos506018400010
dc.keywordsEndoscopic submucosal dissection
dc.keywordsEsophagus
dc.keywordsSeborrheic keratosis
dc.languageEnglish
dc.publisherFederation of Turkish Pathology Societies
dc.relation.grantnoNA
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8687
dc.sourceTurkish Journal of Pathology / Türk Pataloji Dergisi
dc.subjectMedicine
dc.subjectPathology
dc.titleEndoscopic submucosal dissection of seborrheic keratosis-like lesion of the esophagus: a new entity?
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-1002-7202
local.contributor.kuauthorAslan, Fatih

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
8687.pdf
Size:
299.68 KB
Format:
Adobe Portable Document Format