Publication:
Extracranial transport of brain lymphatics via cranial nerve in human

dc.contributor.coauthor 
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentAnimal Laboratory
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAltınöz, Damlasu
dc.contributor.kuauthorÇavdar, Safiye
dc.contributor.kuauthorDemir, Tevriz Dilan
dc.contributor.kuauthorÖzcan, Gülnihal
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteLaboratory
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:39:09Z
dc.date.issued2024
dc.description.abstractExtracranial waste transport from the brain interstitial fluid to the deep cervical lymph node (dCLN) is not extensively understood. The present study aims to show the cranial nerves that have a role in the transport of brain lymphatics vessels (LVs), their localization, diameter, and number using podoplanin (PDPN) and CD31 immunohistochemistry (IHC) and Western blotting. Cranial nerve samples from 6 human cases (3 cadavers, and 3 autopsies) were evaluated for IHC and 3 autopsies for Western blotting. The IHC staining showed LVs along the optic, olfactory, oculomotor, trigeminal, facial, glossopharyngeal, accessory, and vagus nerves. However, no LVs present along the trochlear, abducens, vestibulocochlear, and hypoglossal nerves. The LVs were predominantly localized at the endoneurium of the cranial nerve that has motor components, and LVs in the cranial nerves that had sensory components were present in all 3 layers. The number of LVs accompanying the olfactory, optic, and trigeminal nerves was classified as numerous; oculomotor, glossopharyngeal, vagus, and accessory was moderate; and facial nerves was few. The largest diameter of LVs was in the epineurium and the smallest one was in the endoneurium. The majority of Western blotting results correlated with the IHC. The present findings suggest that specific cranial nerves with variable quantities provide a pathway for the transport of wastes from the brain to dCLN. Thus, the knowledge of the transport of brain lymphatics along cranial nerves may help understand the pathophysiology of various neurological diseases. © 2024 Elsevier B.V.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccess 
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThe authors gratefully acknowledge the use of the services and facilities of the Koç University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Head of Strategy and Budget.
dc.description.volume827
dc.identifier.doi10.1016/j.neulet.2024.137737
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.link 
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85188735333
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2024.137737
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22914
dc.identifier.wos1219307700001
dc.keywordsCranial nerves
dc.keywordsHuman
dc.keywordsImmunohistochemistry
dc.keywordsLymphatic vessels
dc.keywordsWestern blotting
dc.language.isoeng
dc.publisherElsevier Ireland Ltd
dc.relation.grantnoKoç University Research Center for Translational Medicine
dc.relation.ispartofNeuroscience Letters
dc.rights 
dc.subjectBirth defects
dc.subjectHydrocephalus
dc.titleExtracranial transport of brain lymphatics via cranial nerve in human
dc.typeJournal Article
dc.type.other 
dspace.entity.typePublication
local.contributor.kuauthorÇavdar, Safiye
local.contributor.kuauthorAltınöz, Damlasu
local.contributor.kuauthorDemir, Tevriz Dilan
local.contributor.kuauthorAli Gürses, İlke
local.contributor.kuauthorÖzcan, Gülnihal
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1Research Center
local.publication.orgunit1Laboratory
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2Animal Laboratory
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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