Publication: Treatment outcomes of metastasis-directed treatment using(68)Ga-PSMA-PET/CT for oligometastatic or oligorecurrent prostate cancer: Turkish Society for Radiation Oncology group study (TROD 09-002)
dc.contributor.coauthor | Hurmuz, Pervin | |
dc.contributor.coauthor | Onal, Cem | |
dc.contributor.coauthor | Ozyigit, Gokhan | |
dc.contributor.coauthor | Igdem, Sefik | |
dc.contributor.coauthor | Atalar, Banu | |
dc.contributor.coauthor | Sayan, Haluk | |
dc.contributor.coauthor | Akgun, Zuleyha | |
dc.contributor.coauthor | Kurt, Meral | |
dc.contributor.coauthor | Ozkok, Hale Basak | |
dc.contributor.coauthor | Oymak, Ezgi | |
dc.contributor.coauthor | Tilki, Burak | |
dc.contributor.coauthor | Guler, Ozan Cem | |
dc.contributor.coauthor | Mustafayev, Teuto Zoto | |
dc.contributor.coauthor | Saricanbaz, Irem | |
dc.contributor.coauthor | Rzazade, Rashad | |
dc.contributor.coauthor | Akyol, Fadil | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Selek, Uğur | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:37:48Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Purpose The aim of this study was to evaluate the outcomes of(68)Ga prostate-specific membrane antigen (Ga-68-PSMA) positron-emission tomography (PET)/CT-based metastasis-directed treatment (MDT) for oligometastatic prostate cancer (PC). Methods In this multi-institutional study, clinical data of 176 PC patients with 353 lesions receiving MDT between 2014 and 2019 were retrospectively evaluated. All patients had biopsy proven PC with <= 5 metastases detected with(68)Ga-PSMA-PET/CT. MDT was delivered with conventional fractionation or stereotactic body radiotherapy (SBRT) techniques. CTCAE v4.0 was used for acute and RTOG/EORTC Late Radiation Morbidity Scoring Schema was used for late toxicity evaluation. Results At the time of MDT, 59 patients (33.5%) had synchronous and 117 patients (66.5%) had metachronous metastases. Median number of metastases was one and the MDT technique was SBRT in 73.3% patients. The 2-year overall survival (OS) and progression-free survival (PFS) rates were 87.6% and 63.1%, respectively. With a median follow-up of 22.9 months, 9 patients had local recurrence at the irradiated site. The 2-year local control rate at the treated oligometastatic site per patient was 93.2%. In multivariate analysis, an increased number of oligometastases and untreated primary PC were negative predictors for OS; advanced clinical tumor stage, untreated primary PC, BED3 value of <= 108Gy, and MDT with conventional fractionation were negative predictors for PFS. No patient experienced grade >= 3 acute toxicity, but one patient had a late grade 3 toxicity of compression fracture after spinal SBRT. Conclusion Ga-68-PSMA-PET/CT-based MDT is an efficient and safe treatment for oligometastatic PC patients. Proper patient selection might improve treatment outcomes. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 11 | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 196 | |
dc.identifier.doi | 10.1007/s00066-020-01660-6 | |
dc.identifier.eissn | 1439-099X | |
dc.identifier.issn | 0179-7158 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85087421488 | |
dc.identifier.uri | https://doi.org/10.1007/s00066-020-01660-6 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/12869 | |
dc.identifier.wos | 545850300001 | |
dc.keywords | Prostate adenocarcinoma | |
dc.keywords | Stereotactic body radiotherapy | |
dc.keywords | PSMA PET | |
dc.keywords | Oligometastasis | |
dc.keywords | Survival Stereotactic body radiotherapy | |
dc.keywords | Curative treatment | |
dc.keywords | Recurrence | |
dc.keywords | Therapy | |
dc.keywords | PET/CT | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartof | Strahlentherapie und Onkologie | |
dc.subject | Oncology | |
dc.subject | Radiology, Nuclear Medicine and medical imaging | |
dc.title | Treatment outcomes of metastasis-directed treatment using(68)Ga-PSMA-PET/CT for oligometastatic or oligorecurrent prostate cancer: Turkish Society for Radiation Oncology group study (TROD 09-002) | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Selek, Uğur | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
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relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
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