Publication:
Impact of concomitant obstructive sleep apnea on pulmonary involvement and main pulmonary artery diameter in adults with scleroderma

dc.contributor.coauthorYakut, Tuğçe
dc.contributor.coauthorBalcan, Baran
dc.contributor.coauthorKarakurt, Sait
dc.contributor.coauthorDireskeneli, Haner
dc.contributor.coauthorYalçınkaya, Yasemin
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorPeker, Yüksel
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:20:01Z
dc.date.issued2020
dc.description.abstractPurpose: pulmonary involvement is common in adults with scleroderma. The effect of concomitant obstructive sleep apnea (OSA) on risk for pulmonary hypertension in scleroderma is unknown. An enlarged main pulmonary artery diameter (mPAD) derived from chest computer tomography (CT) is a useful predictor of pulmonary hypertension. We addressed the effect of OSA on pulmonary involvement and enlarged mPAD in adults with scleroderma. Methods: all participants underwent pulmonary function testing, carbon monoxide diffusion capacity, chest CT, and overnight sleep recording with home sleep apnea testing. OSA diagnosis was based on an apnea-hypopnea index (AHI) >= 15/h. Oxygen desaturation index (ODI) was also recorded. Scleroderma involvement of the lungs was defined as the Warrick score >= 7 based on the CT findings. Enlarged mPAD was defined as an mPAD >= 29 mm in men and >= 27 mm in women. Results: after exclusions, 62 patients (58 women) were included. OSA was found among 20 (32%), 17/42 (38%) in the limited cutaneous type, and 3/20 (15%) in the diffuse cutaneous type (p = 0.08). Scleroderma involvement of the lungs was observed in 40 participants (65% in OSA vs 64% in no-OSA; n.s.). Enlarged mPAD was measured in 16 participants, 10 of 20 (50%) in the OSA group and 6 of 17 (14%) in the no-OSA group (p = 0.003). OSA was associated with enlarged mPAD (odds ratio 4.7, 95% confidence interval 1.1-20.9; p = 0.042) independent of age, body mass index, and pulmonary involvement. There was a linear relationship between mPAD and AHI (r = 0.37; p = 0.003) as well as ODI (r = 0.41; p < 0.001). Conclusions: in this cohort, OSA was associated with risk for pulmonary hypertension independent of pulmonary involvement. These findings suggest that assessing the effect of therapy for concomitant OSA in patients with scleroderma is warranted.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipUniversity of Gothenburg
dc.description.versionPublisher version
dc.description.volume25
dc.identifier.doi10.1007/s11325-020-02059-4
dc.identifier.eissn1522-1709
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02194
dc.identifier.issn1520-9512
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85083768850
dc.identifier.urihttps://doi.org/10.1007/s11325-020-02059-4
dc.identifier.wos526997600001
dc.keywordsObstructive sleep apnea
dc.keywordsScleroderma
dc.keywordsPulmonary involvement
dc.keywordsPulmonary hypertension
dc.language.isoeng
dc.publisherSpringer
dc.relation.grantnoNA
dc.relation.ispartofSleep and Breathing
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8797
dc.subjectClinical neurology
dc.subjectRespiratory system
dc.titleImpact of concomitant obstructive sleep apnea on pulmonary involvement and main pulmonary artery diameter in adults with scleroderma
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorPeker, Yüksel
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
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