Publication:
The possible role of the glucose-6-phosphate dehydrogenase enzyme deficiency in the polyneuropathies

dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAydemir, Duygu
dc.contributor.kuauthorUlusu, Nuriye Nuray
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:02:48Z
dc.date.issued2020
dc.description.abstractGlucose is the main energy source of the various types of cells and largely metabolized by either glycolysis or pentose phosphate pathway (PPP). Glucose-6-phosphate dehydrogenase (G6PD, glucose 6-phosphate (G6P): NADP (+) oxidoreductase, EC 1.1.1.49) is the first and rate limiting enzyme of the oxidative branch of the PPP. This enzyme found in many species from bacteria to humans and is found in all cell types. G6PD deficiency is the most common enzyme deficiency affecting 400 million people worldwide. However, moderate G6PD deficiency may not give symptoms but can lead to various neurological and neurodegenerative disorders including polyneuropathies. Both inflammation and oxidative stress play a major role in the formation of the neurological disorders, however, G6PD gives advantage to brain and nerve cells to fight against oxidative stress, neurodegeneration, neuronal survival and aging. In conclusion, G6PD plays vital role to maintain homeostasis of lipid, redox and energy metabolisms. Thus, impairment in the G6PD activity may cause elevated levels of oxidative stress involved in the formation of the neurodegeneration and may involve in the primary cause of idiopathic sensory-motor polyneuropathy.
dc.description.indexedbyWOS
dc.description.indexedbyTR Dizin
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume4
dc.identifier.doi10.30621/jbachs.2020.1151
dc.identifier.eissn2564-7288
dc.identifier.issn2458-8938
dc.identifier.quartileQ4
dc.identifier.urihttps://doi.org/10.30621/jbachs.2020.1151
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8359
dc.identifier.wos579406500005
dc.keywordsGlucose-6-phosphate dehydrogenase
dc.keywordsOxidative stress
dc.keywordsBrain
dc.keywordsGlucose metabolism oxidative stress
dc.keywordsNeurodegenerative disorders
dc.keywordsGlutathione-reductase
dc.keywordsDiabetic-rats
dc.keywordsBrain
dc.keywordsGlucose
dc.keywordsAnxiety
dc.keywordsPurfication
dc.keywordsMetabolism
dc.keywordsActivation
dc.language.isoeng
dc.publisherDokuz Eylul Univ Inst Health Sciences
dc.relation.ispartofJournal of Basic and Clinical Health Sciences
dc.subjectHealth care sciences & services
dc.titleThe possible role of the glucose-6-phosphate dehydrogenase enzyme deficiency in the polyneuropathies
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAydemir, Duygu
local.contributor.kuauthorUlusu, Nuriye Nuray
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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