Evaluation of SARS-CoV-2 with a biophysical perspective

Abstract

This paper intends to contribute to the collaborative efforts of the scientific community by providing a literature review of the status of the coronavirus research by adding a multi-disciplinary perspective and looking into a broad spectrum of SARS-CoV-2 studies on virus molecular structure, biophysical approach, electrostatic interaction and UVC rays. The paper identifies future research directions for each group of studies and points out remaining questions on the way related to COVID-19. The summary of the literature review will intend to assist future studies; provide a biophysical understanding of the virus interaction with host cells and help better identify antiviral therapy and the development of new vaccines/drugs to tackle COVID-19 and any virus outbreak. In addition to the electrostatic interactions of SARS-CoV-2, this paper also discusses whether UVC rays are a safe alternative to many chemical sterilization methods which are frequently used in our daily life since the beginning of the COVID-19 outbreak and whose health effects are controversial. This article also briefly discusses the relationship of some trace elements with COVID-19 infection. In conclusion, focusing on biophysical mechanisms of virus–cell interactions with a broad perspective has potential to give a different approach to the reader for future treatment methods.