Publication:
Low serm Fibroblast Growth Factor-21 levels is not associated with Carotid intima-media thickness in acromegaly patients

dc.contributor.coauthorUygur, M.M.
dc.contributor.coauthorGogas, Yavuz D.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorDereli, Dilek Yazıcı
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:23:22Z
dc.date.issued2022
dc.description.abstractIntroduction: Elevated fibroblast growth factor-21 (FGF-21) levels are related to carotid intima-media thickness (CIMT), a well-established marker of atherosclerosis. Acromegaly has also been linked to increased CIMT. There has been no data considering the association between FGF-21 levels and atherosclerosis in acromegaly patients. This study aimed to evaluate FGF-21 levels and CIMT in acromegalic patients in relation to atherosclerotic complications. Design: Case–control study. Materials and methods: The study group included 70 acromegaly patients and 72 healthy volunteers from the Department of Endocrinology and Metabolism Disease, Marmara University Medical School. FGF-21, growth hormone, insulin-like growth factor I, lipids, glucose, insulin levels were assessed. CIMT was measured from the common carotid artery wall on B-mode ultrasound. Results: Median FGF-21 levels were significantly lower in the acromegaly group than in the control group. CIMT was higher in acromegaly patients compared to controls. Although there was no correlation between FGF-21 levels and CIMT in patients with acromegaly, a positive correlation was found between high-density lipoprotein-cholesterol and FGF-21 levels. Glucose metabolic markers were the determining factors of the FGF-21 levels in acromegaly patients. Conclusion: Our study is the first to examine the relationship between serum FGF-21 levels and atherosclerosis in acromegaly patients. The lower serum FGF-21 levels in acromegaly subjects might be associated with the improving effects of growth hormone on liver fat. Acromegaly was linked to higher CIMT, but there was no correlation between FGF-21 levels and CIMT. The role of FGF-21 in acromegaly as a marker of atherosclerosis requires additional research. © 2022, The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.indexedbyWOS
dc.description.issue7
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume45
dc.identifier.doi10.1007/s40618-022-01775-w
dc.identifier.issn0391-4097
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85127302469
dc.identifier.urihttps://hdl.handle.net/20.500.14288/11235
dc.keywordsAcromegaly
dc.keywordsAtherosclerosis
dc.keywordsCardiovascular disease
dc.keywordsCarotid intima-media thickness
dc.keywordsFGF-21
dc.keywordsIGF-1 cabergoline
dc.language.isoeng
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofJournal of Endocrinological Investigation
dc.subjectFibroblast growth factor 21
dc.subjectAnimals
dc.subjectHuman FGF19 protein
dc.titleLow serm Fibroblast Growth Factor-21 levels is not associated with Carotid intima-media thickness in acromegaly patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorDereli, Dilek Yazıcı
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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