Publication: Low serm Fibroblast Growth Factor-21 levels is not associated with Carotid intima-media thickness in acromegaly patients
dc.contributor.coauthor | Uygur, M.M. | |
dc.contributor.coauthor | Gogas, Yavuz D. | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Dereli, Dilek Yazıcı | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:23:22Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Introduction: Elevated fibroblast growth factor-21 (FGF-21) levels are related to carotid intima-media thickness (CIMT), a well-established marker of atherosclerosis. Acromegaly has also been linked to increased CIMT. There has been no data considering the association between FGF-21 levels and atherosclerosis in acromegaly patients. This study aimed to evaluate FGF-21 levels and CIMT in acromegalic patients in relation to atherosclerotic complications. Design: Case–control study. Materials and methods: The study group included 70 acromegaly patients and 72 healthy volunteers from the Department of Endocrinology and Metabolism Disease, Marmara University Medical School. FGF-21, growth hormone, insulin-like growth factor I, lipids, glucose, insulin levels were assessed. CIMT was measured from the common carotid artery wall on B-mode ultrasound. Results: Median FGF-21 levels were significantly lower in the acromegaly group than in the control group. CIMT was higher in acromegaly patients compared to controls. Although there was no correlation between FGF-21 levels and CIMT in patients with acromegaly, a positive correlation was found between high-density lipoprotein-cholesterol and FGF-21 levels. Glucose metabolic markers were the determining factors of the FGF-21 levels in acromegaly patients. Conclusion: Our study is the first to examine the relationship between serum FGF-21 levels and atherosclerosis in acromegaly patients. The lower serum FGF-21 levels in acromegaly subjects might be associated with the improving effects of growth hormone on liver fat. Acromegaly was linked to higher CIMT, but there was no correlation between FGF-21 levels and CIMT. The role of FGF-21 in acromegaly as a marker of atherosclerosis requires additional research. © 2022, The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.indexedby | WOS | |
dc.description.issue | 7 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 45 | |
dc.identifier.doi | 10.1007/s40618-022-01775-w | |
dc.identifier.issn | 0391-4097 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85127302469 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/11235 | |
dc.keywords | Acromegaly | |
dc.keywords | Atherosclerosis | |
dc.keywords | Cardiovascular disease | |
dc.keywords | Carotid intima-media thickness | |
dc.keywords | FGF-21 | |
dc.keywords | IGF-1 cabergoline | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media Deutschland GmbH | |
dc.relation.ispartof | Journal of Endocrinological Investigation | |
dc.subject | Fibroblast growth factor 21 | |
dc.subject | Animals | |
dc.subject | Human FGF19 protein | |
dc.title | Low serm Fibroblast Growth Factor-21 levels is not associated with Carotid intima-media thickness in acromegaly patients | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Dereli, Dilek Yazıcı | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
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relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
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