Publication: Pancreatoblastoma: cytologic and histologic analysis of 12 adult cases reveals helpful criteria in their diagnosis and distinction from common mimics
dc.contributor.coauthor | Reid, Michelle D. | |
dc.contributor.coauthor | Bhattarai, Shristi | |
dc.contributor.coauthor | Graham, Rondell P. | |
dc.contributor.coauthor | Pehlivanoglu, Burcin | |
dc.contributor.coauthor | Sigel, Carlie S. | |
dc.contributor.coauthor | Shi, Jiaqi | |
dc.contributor.coauthor | Saqi, Anjali | |
dc.contributor.coauthor | Shirazi, Maryam | |
dc.contributor.coauthor | Xue, Yue | |
dc.contributor.coauthor | Basturk, Olca | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Adsay, Nazmi Volkan | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:45:34Z | |
dc.date.issued | 2019 | |
dc.description.abstract | Background Pancreatoblastoma (PBL) is a rare malignant pancreatic tumor seen predominantly in childhood, and its cytologic diagnosis remains challenging. Methods Twelve fine-needle-aspirations from 11 adults were analyzed. Results In total, 6 men and 5 women (median age, 45 years; age range, 32-60 years) had tumors measuring a median 5.6 cm (range, 2.5-12 cm) located in the pancreatic head (n = 7) or tail (n = 4), including 3 with familial adenomatous polyposis (FAP)/FAP-related syndromes and 4 with metastasis at diagnosis. The median follow-up was 39.8 months (range, 0.8-348 months), and 5 patients died of disease. The original cytology diagnoses were: PBL (n = 2), neuroendocrine neoplasm (n = 2), poorly differentiated neuroendocrine carcinoma (n = 2), well differentiated neuroendocrine tumor (n = 1), poorly differentiated carcinoma (n = 2), "positive for malignancy" (n = 1), acinar cell carcinoma (n = 1), and epithelioid neoplasm with endocrine and acinar differentiation versus PBL (n = 1). Universal cytopathologic findings included hypercellularity; 3-dimensional clusters; and single, monotonous, blast-like cells that were from 1.5 to 2.0 times the size of red blood cells with high nuclear-to-cytoplasmic ratio, fine chromatin, small, distinct nucleoli, and a resemblance to well differentiated neuroendocrine tumor and poorly differentiated neuroendocrine carcinoma. Branching pseudopapillae (n = 7) and grooved nuclei (n = 3) raised the differential diagnosis of solid-pseudopapillary neoplasm, but with more atypia. Uncommon features included pleomorphism (n = 4) and numerous mitoses (n = 1). Squamoid morules were seen on smears (n = 5) or cell blocks (n = 6) in 70% of patients and were characterized by epithelioid cells with elongated, streaming nuclei, fine chromatin, absent nucleoli, and positive nuclear beta-catenin (n = 6 of 8). The median Ki-67 index was 21% (range, 2%-70%), and neuroendocrine marker expression was common (100%), but acinar markers were variable (63%). Conclusions A combination of cytologic findings in PBL, including a predominant population of primitive blast-like cells, subtle squamoid morules, frequent neuroendocrine and variable acinar phenotype, should facilitate accurate cytologic diagnosis and distinction from common mimics. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 11 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 127 | |
dc.identifier.doi | 10.1002/cncy.22187 | |
dc.identifier.eissn | 1934-6638 | |
dc.identifier.issn | 1934-662X | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85073963986 | |
dc.identifier.uri | https://doi.org/10.1002/cncy.22187 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/13858 | |
dc.identifier.wos | 489550300001 | |
dc.keywords | Cytology | |
dc.keywords | Fine-needle aspiration (FNA) | |
dc.keywords | Pancreas | |
dc.keywords | Pancreatoblastoma | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | Cancer Cytopathology | |
dc.subject | Oncology | |
dc.subject | Pathology | |
dc.title | Pancreatoblastoma: cytologic and histologic analysis of 12 adult cases reveals helpful criteria in their diagnosis and distinction from common mimics | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Adsay, Nazmi Volkan | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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