Publication:
Changing trends in the etiology of liver transplantation in Turkiye: a multicenter study

dc.contributor.coauthorAkarsu, Mesut
dc.contributor.coauthorDolu, Süleyman
dc.contributor.coauthorHarputluoğlu, Murat
dc.contributor.coauthorYılmaz, Sezai
dc.contributor.coauthorPolat, Kamil Yalçın
dc.contributor.coauthorDinçer, Dinç
dc.contributor.coauthorAdanır, Haydar
dc.contributor.coauthorTuran, İlker
dc.contributor.coauthorGünsar, Fulya
dc.contributor.coauthorKarasu, Zeki
dc.contributor.coauthorGökcan, Hale
dc.contributor.coauthorKarademir, Sedat
dc.contributor.coauthorKabacam, Gökhan
dc.contributor.coauthorKayhan, Meral Akdoğan
dc.contributor.coauthorKıyıcı, Murat
dc.contributor.coauthorGülşen, Murat Taner
dc.contributor.coauthorBalaban, Yasemin
dc.contributor.coauthorDoğrul, Ahmet Bülent
dc.contributor.coauthorSenkaya, Ali
dc.contributor.coauthorEllik, Zeynep Melekoğlu
dc.contributor.coauthorEren, Fatih
dc.contributor.coauthorİdilman, Ramazan
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAkyıldız, Murat
dc.contributor.kuauthorGençdal, Genco
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:37:38Z
dc.date.issued2024
dc.description.abstractBackground and aim: This study aimed to identify the indications for liver transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT. Materials and methods: We conducted a multicenter cross-sectional observational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients. Results: The mean age of patients was 50.3 +/- 15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and alcohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001). Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.indexedbyTR Dizin
dc.description.issue1
dc.description.openaccessBronze, Green Published
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume5
dc.identifier.doi10.14744/hf.2023.2023.0010
dc.identifier.eissn2757-7392
dc.identifier.issn1307-5888
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85183838612
dc.identifier.urihttps://doi.org/10.14744/hf.2023.2023.0010
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22434
dc.identifier.wos1163820300009
dc.keywordsEtiology
dc.keywordsHBV
dc.keywordsNAFLD
dc.keywordsLiver transplantation
dc.language.isoeng
dc.publisherKare Publ
dc.relation.ispartofHepatology Forum
dc.subjectGastroenterology and hepatology
dc.titleChanging trends in the etiology of liver transplantation in Turkiye: a multicenter study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAkyıldız, Murat
local.contributor.kuauthorGençdal, Genco
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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