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Clinical and demographic aspects of Paget disease of bone: a multicentric study from Turkey

dc.contributor.coauthorYavuz, Dilek Gogas
dc.contributor.coauthorAytürk, Semra
dc.contributor.coauthorÇetinkalp, Şevki
dc.contributor.coauthorBayraktar, Fırat
dc.contributor.coauthorKulaksızoğlu, Mustafa
dc.contributor.coauthorHekimsoy, Zeliha
dc.contributor.coauthorAydın, Hasan
dc.contributor.coauthorUygur, Melin
dc.contributor.coauthorDeniz, Ferhat
dc.contributor.coauthorİpekçi, Süleyman
dc.contributor.coauthorAtmaca, Ayşegül
dc.contributor.coauthorSaraç, Fulden
dc.contributor.coauthorÖzdemir, Nilüfer
dc.contributor.coauthorCantürk, Zeynep
dc.contributor.coauthorMert, Meral
dc.contributor.coauthorSancak, Seda
dc.contributor.coauthorErtörer, Eda
dc.contributor.coauthorDuran, Cevdet
dc.contributor.coauthorAkarsu, Ersin
dc.contributor.coauthorSelek, Alev
dc.contributor.coauthorGürlek, Alper
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorDeyneli, Oğuzhan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:45:27Z
dc.date.issued2020
dc.description.abstractObjective: Paget disease of bone (PDB) is a metabolic bone disease that has been rarely reported in the Eastern countries. This study aimed to evaluate the clinical and demographic characteristics of patients with PDB followed up at endocrinology clinics in Turkey. Methods: an invitation was sent to tertiary endocrinology clinics to complete a survey on the demographic, clinical, radiological, and laboratory parameters, as well as treatment modalities of patients with PDB. This study enrolled clinically and radiologically proven 185 patients with PDB from 18 endocrinology centers based in 10 cities of Turkey. Results: this cohort of PDB had female preponderance (women/men: 105/80) with a mean age, during diagnosis, of 57±10 years. Most of the patients (59.6%) were symptomatic at diagnosis. Bone pain and headache were the predominant clinical symptoms. Polyostotic disease was observed in 67.5% (n=125) of patients. Frequently affected bones were skull (41.6%), pelvis (53.5%), spine (41%), and femur (25.4%). Moreover, 17 patients with skull involvement had hearing loss. Mean serum alkaline phosphatase (ALP) level (552±652 IU/L; range: 280-5762 IU/L) was over the normal reference cutoff with normal serum calcium levels. Intravenous bisphosphonates (zoledronic acid, 5 mg; pamidronate, 60-90 mg) were the most used drugs (75%) for the treatment of PDB. Most of the patients (87.1%) treated with intravenous bisphosphonates responded well, with a decrease in serum ALP level (117±114 IU/L) in the 12th month of therapy. Furthermore, 16 patients relapsed after the second year of therapy; 3 patients did not respond to the initial intravenous bisphosphonate treatment. Conclusion: the patients with PDB followed up by endocrinology clinics of Turkey exhibited polyostotic disease with classical clinical, radiological, and biochemical features and women's predominance with good response to intravenous bisphosphonate therapy.
dc.description.fulltextYES
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume8
dc.identifier.doi10.5152/eurjrheum.2020.20139
dc.identifier.eissn2148-4279
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02562
dc.identifier.issn2147-9720
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.5152/eurjrheum.2020.20139
dc.keywordsPaget disease of bone
dc.keywordsPolyostotic disease
dc.keywordsSerum alkaline phosphatase
dc.keywordsBisphosphonate therapy
dc.language.isoeng
dc.publisherAves
dc.relation.grantnoNA
dc.relation.ispartofEuropean Journal of Rheumatology
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9201
dc.subjectMedicine
dc.subjectEndocrinology metabolism
dc.titleClinical and demographic aspects of Paget disease of bone: a multicentric study from Turkey
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorDeyneli, Oğuzhan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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