Publication:
The systemic inflammation response index efficiently discriminates between the failure patterns of patients with isocitrate dehydrogenase wild-type glioblastoma following radiochemotherapy with FLAIR-Based gross tumor volume delineation

dc.contributor.coauthorAygun, Murat Serhat
dc.contributor.coauthorTopkan, Erkan
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAkdemir, Eyüb Yaşar
dc.contributor.kuauthorBölükbaşı, Yasemin
dc.contributor.kuauthorDurankuş, Nilüfer Kılıç
dc.contributor.kuauthorSelek, Uğur
dc.contributor.kuauthorŞenyürek, Şükran
dc.contributor.kuauthorSezen, Duygu
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:57:41Z
dc.date.issued2024
dc.description.abstractBackground/Objectives: The objective of this study was to assess the connection between the systemic inflammation response index (SIRI) values and failure patterns of patients with IDH wild-type glioblastoma (GB) who underwent radiotherapy (RT) with FLAIR-based gross tumor volume (GTV) delineation. Methods: Seventy-one patients who received RT at a dose of 60 Gy to the GTV and 50 Gy to the clinical target volume (CTV) and had documented recurrence were retrospectively analyzed. Each patient's maximum distance of recurrence (MDR) from the GTV was documented in whichever plane it extended the farthest. The failure patterns were described as intra-GTV, in-CTV/out-GTV, distant, and intra-GTV and distant. For analytical purposes, the failure pattern was categorized into two groups, namely Group 1, intra-GTV or in-CTV/out-GTV, and Group 2, distant or intra-GTV and distant. The SIRI was calculated before surgery and corticosteroid administration. A receiver operating characteristic (ROC) curve analysis was used to determine the optimal SIRI cut-off that distinguishes between the different failure patterns. Results: Failure occurred as follows: intra-GTV in 40 (56.3%), in-CTV/out-GTV in 4 (5.6%), distant in 18 (25.4%), and intra-GTV + distant in 9 (12.7%) patients. The mean MDR was 13.5 mm, and recurrent lesions extended beyond 15 mm in only seven patients. Patients with an SIRI score >= 3 demonstrated a significantly higher incidence of Group 1 failure patterns than their counterparts with an SIRI score < 3 (74.3% vs. 50.0%;p = 0.035). Conclusions: The present results show that using the SIRI with a cut-off value of >= 3 significantly predicts failure patterns. Additionally, the margin for the GTV can be safely reduced to 15 mm when using FLAIR-based target delineation in patients with GB.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.3390/brainsci14090922
dc.identifier.eissn2076-3425
dc.identifier.issue9
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85205039052
dc.identifier.urihttps://doi.org/10.3390/brainsci14090922
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27280
dc.identifier.volume14
dc.identifier.wos1326222400001
dc.keywordsGlioblastoma
dc.keywordsRadiochemotherapy
dc.keywordsFailure pattern
dc.keywordsSystemic inflammation response index
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofBRAIN SCIENCES
dc.subjectNeurosciences
dc.titleThe systemic inflammation response index efficiently discriminates between the failure patterns of patients with isocitrate dehydrogenase wild-type glioblastoma following radiochemotherapy with FLAIR-Based gross tumor volume delineation
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSelek, Uğur
local.contributor.kuauthorDurankuş, Nilüfer Kılıç
local.contributor.kuauthorŞenyürek, Şükran
local.contributor.kuauthorSezen, Duygu
local.contributor.kuauthorBölükbaşı, Yasemin
local.contributor.kuauthorAkdemir, Eyüb Yaşar
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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