Publication:
Cardiovascular effects of continuous positive airway pressure treatment in patients with obstructive sleep apnea: a meta-analysis

dc.contributor.coauthorAfsar, Baris
dc.contributor.coauthorSiriopol, Dimitrie
dc.contributor.coauthorKanbay, Asiye
dc.contributor.coauthorCovic, Adrian
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorAslan, Gamze
dc.contributor.kuauthorŞal, Oğuzhan
dc.contributor.kuauthorBenli, Çağhan
dc.contributor.kuauthorOkçuoğlu, John
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuprofileDoctor
dc.contributor.kuprofileUndergraduate Student
dc.contributor.kuprofileUndergraduate Student
dc.contributor.kuprofileUndergraduate Student
dc.contributor.kuprofileFaculty Member
dc.contributor.yokidN/A
dc.contributor.yokid341966
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid110580
dc.date.accessioned2024-11-09T23:46:23Z
dc.date.issued2018
dc.description.abstractContinuous positive airway pressure (CPAP) is the first-line treatment of obstructive sleep apnea (OSA). Obstructive sleep apnea is a predictor of cardiovascular (CV) events. In this meta-analysis, we evaluated the effect of CPAP on left ventricular ejection fraction (LVEF), CV events, CV mortality, and all-cause mortality in patients with OSA. Nine articles (n = 9610 patients) were analyzed. Four different meta-analyses were performed: evaluation of LVEF, assessment of all-cause mortality, CV mortality, and CV events. Continuous positive airway pressure treatment was associated with a significant increase in LVEF (mean difference: 2.1%, 95% confidence interval [CI]: 0.8%-3.4%). There was a nonsignificant reduction in all-cause mortality (hazard ratio [HR]: 0.92, 95% CI: 0.73-1.15) but a significant reduction of 66% in the risk of CV mortality associated with the CPAP treatment (HR: 0.34, 95% CI: 0.17-0.68, P = .002). There was a nonsignificant reduction in the risk of CV events in the CPAP-treated patients (HR: 0.84, 95% CI: 0.60-1.18, P = .31). Our meta-analyses showed that CPAP treatment improves LVEF and could have a beneficial effect on CV mortality.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.volume69
dc.identifier.doi10.1177/0003319717709175
dc.identifier.eissn1940-1574
dc.identifier.issn0003-3197
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85041609676
dc.identifier.urihttp://dx.doi.org/10.1177/0003319717709175
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13957
dc.identifier.wos423753800003
dc.keywordsContinuous positive airway pressure
dc.keywordsCardiovascular events
dc.keywordsMeta-analysis
dc.keywordsObstructive sleep apnea
dc.keywordsLeft ventricular ejection fraction independent risk-factor
dc.keywordsAll-cause mortality
dc.keywordsHeart-failure
dc.keywordsResistant hypertension
dc.keywordsPlatelet-function
dc.keywordsFollow-up
dc.keywordsAssociation
dc.keywordsDisease
dc.keywordsHypopnea
dc.keywordsHypoxia
dc.languageEnglish
dc.publisherSage
dc.sourceAngiology
dc.subjectPeripheral vascular disease
dc.titleCardiovascular effects of continuous positive airway pressure treatment in patients with obstructive sleep apnea: a meta-analysis
dc.typeReview
dspace.entity.typePublication
local.contributor.authorid0000-0003-4000-3292
local.contributor.authorid0000-0002-8771-8263
local.contributor.authorid0000-0003-4064-6757
local.contributor.authorid0000-0002-8609-3054
local.contributor.authorid0000-0002-1297-0675
local.contributor.kuauthorAslan, Gamze
local.contributor.kuauthorŞal, Oğuzhan
local.contributor.kuauthorBenli, Çağhan
local.contributor.kuauthorOkçuoğlu, John
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2KUH (Koç University Hospital)
relation.isOrgUnitOfPublicationf91d21f0-6b13-46ce-939a-db68e4c8d2ab
relation.isOrgUnitOfPublication.latestForDiscoveryf91d21f0-6b13-46ce-939a-db68e4c8d2ab

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