Publication: Does pituitary suppression affect live birth rate in women with congenital hypogonadotrophic hypogonadism undergoing intra-cytoplasmic sperm injection? a multicenter cohort study
dc.contributor.coauthor | Mumusoglu, Sezcan | |
dc.contributor.coauthor | Turan, Volkan | |
dc.contributor.coauthor | Demir, Berfu | |
dc.contributor.coauthor | Kahyaoglu, Inci | |
dc.contributor.coauthor | Aslan, Kiper | |
dc.contributor.coauthor | Ata, Ayse Seyhan | |
dc.contributor.coauthor | Yilmaz, Bulent | |
dc.contributor.coauthor | Avci, Berrin | |
dc.contributor.coauthor | Uncu, Gurkan | |
dc.contributor.coauthor | Bozdag, Gurkan | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Ata, Mustafa Barış | |
dc.contributor.kuauthor | Yakın, Kayhan | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:42:37Z | |
dc.date.issued | 2017 | |
dc.description.abstract | In this retrospective multicenter cohort study, women with congenital hypogonadotrophic hypogonadism (CHH) (n = 57) who underwent intra-cytoplasmic sperm injection in-between 2010-2014 were compared to age-matched controls with tubal factor infertility (n = 114) to assess ovarian stimulation cycle and pregnancy outcomes. Live birth rates (LBRs) per started cycle were 31.6 and 24.6% in CHH and controls groups, respectively (p = 0.36). Comparable success rates were also confirmed with the logistic regression analysis (OR: 1.44, 95% CI: 0.78-2.67, p = 0.24). of the 57 women with CHH, 19 were stimulated with the gonadotropin-releasing hormone (GnRH) antagonist protocol, 13 with the long-GnRH-agonist protocol. Pituitary suppression (PS) was not employed in the remaining 25 cases. Compared to women with PS, women without PS had significantly higher embryo implantation rates (21.6 versus 52.6%, p = 0.03). Although there was a trend favoring no PS, LBRs (25.0 versus 40.0%, p = 0.26) per cycle were short of statistical significance. LBRs per cycle (57.1 versus 31.2%, p = 0.11) and miscarriage rates (11.1 versus 16.7%, p = 0.75) were similar between CHH women who were given estrogen + progesterone and progesterone alone to support the luteal phase. In conclusion, the optimal stimulation protocol appears to be exogenous gonadotropin stimulation alone, without PS, and progesterone-only luteal phase support in CHH patients. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 9 | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 33 | |
dc.identifier.doi | 10.1080/09513590.2017.1318278 | |
dc.identifier.eissn | 1473-0766 | |
dc.identifier.issn | 0951-3590 | |
dc.identifier.quartile | Q3 | |
dc.identifier.scopus | 2-s2.0-85018173476 | |
dc.identifier.uri | https://doi.org/10.1080/09513590.2017.1318278 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/13354 | |
dc.identifier.wos | 413707600016 | |
dc.keywords | Controlled ovarian stimulation | |
dc.keywords | Congenital hypogonadotrophic hypogonadism | |
dc.keywords | GnRH AG/ANTAG | |
dc.keywords | Luteal support | |
dc.keywords | Pituitary suppression | |
dc.language.iso | eng | |
dc.publisher | Taylor & Francis | |
dc.relation.ispartof | Gynecological Endocrinology | |
dc.subject | Endocrinology and metabolism | |
dc.subject | Obstetrics and gynecology | |
dc.title | Does pituitary suppression affect live birth rate in women with congenital hypogonadotrophic hypogonadism undergoing intra-cytoplasmic sperm injection? a multicenter cohort study | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Ata, Mustafa Barış | |
local.contributor.kuauthor | Yakın, Kayhan | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
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