Publication:
Does pituitary suppression affect live birth rate in women with congenital hypogonadotrophic hypogonadism undergoing intra-cytoplasmic sperm injection? a multicenter cohort study

dc.contributor.coauthorMumusoglu, Sezcan
dc.contributor.coauthorTuran, Volkan
dc.contributor.coauthorDemir, Berfu
dc.contributor.coauthorKahyaoglu, Inci
dc.contributor.coauthorAslan, Kiper
dc.contributor.coauthorAta, Ayse Seyhan
dc.contributor.coauthorYilmaz, Bulent
dc.contributor.coauthorAvci, Berrin
dc.contributor.coauthorUncu, Gurkan
dc.contributor.coauthorBozdag, Gurkan
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAta, Mustafa Barış
dc.contributor.kuauthorYakın, Kayhan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:42:37Z
dc.date.issued2017
dc.description.abstractIn this retrospective multicenter cohort study, women with congenital hypogonadotrophic hypogonadism (CHH) (n = 57) who underwent intra-cytoplasmic sperm injection in-between 2010-2014 were compared to age-matched controls with tubal factor infertility (n = 114) to assess ovarian stimulation cycle and pregnancy outcomes. Live birth rates (LBRs) per started cycle were 31.6 and 24.6% in CHH and controls groups, respectively (p = 0.36). Comparable success rates were also confirmed with the logistic regression analysis (OR: 1.44, 95% CI: 0.78-2.67, p = 0.24). of the 57 women with CHH, 19 were stimulated with the gonadotropin-releasing hormone (GnRH) antagonist protocol, 13 with the long-GnRH-agonist protocol. Pituitary suppression (PS) was not employed in the remaining 25 cases. Compared to women with PS, women without PS had significantly higher embryo implantation rates (21.6 versus 52.6%, p = 0.03). Although there was a trend favoring no PS, LBRs (25.0 versus 40.0%, p = 0.26) per cycle were short of statistical significance. LBRs per cycle (57.1 versus 31.2%, p = 0.11) and miscarriage rates (11.1 versus 16.7%, p = 0.75) were similar between CHH women who were given estrogen + progesterone and progesterone alone to support the luteal phase. In conclusion, the optimal stimulation protocol appears to be exogenous gonadotropin stimulation alone, without PS, and progesterone-only luteal phase support in CHH patients.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue9
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume33
dc.identifier.doi10.1080/09513590.2017.1318278
dc.identifier.eissn1473-0766
dc.identifier.issn0951-3590
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85018173476
dc.identifier.urihttps://doi.org/10.1080/09513590.2017.1318278
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13354
dc.identifier.wos413707600016
dc.keywordsControlled ovarian stimulation
dc.keywordsCongenital hypogonadotrophic hypogonadism
dc.keywordsGnRH AG/ANTAG
dc.keywordsLuteal support
dc.keywordsPituitary suppression
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofGynecological Endocrinology
dc.subjectEndocrinology and metabolism
dc.subjectObstetrics and gynecology
dc.titleDoes pituitary suppression affect live birth rate in women with congenital hypogonadotrophic hypogonadism undergoing intra-cytoplasmic sperm injection? a multicenter cohort study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAta, Mustafa Barış
local.contributor.kuauthorYakın, Kayhan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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