Publication:
Effect of oral nitrates on all-cause mortality and hospitalization in heart failure patients with reduced ejection fraction: a propensity-matched analysis

dc.contributor.coauthorKandemir, Ayşen Şimşek
dc.contributor.coauthorKaraüzüm, Kurtuluş
dc.contributor.coauthorBaydemir, Canan
dc.contributor.coauthorKaraüzüm, İrem Yılmaz
dc.contributor.coauthorBozyel, Serdar
dc.contributor.coauthorKozdağ, Güliz
dc.contributor.coauthorAğır, Ayşen Ağaçdiken
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorUral, Dilek
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:09:36Z
dc.date.issued2017
dc.description.abstractBackground: Hydralazine-nitrate combination is recommended for patients with heart failure with reduced ejection fraction (HFrEF)/systolic heart failure who are symptomatic despite guideline-directed medical therapy (GDMT). Use of nitrates alone for this indication is not well-established. This study aims to evaluate the effect of oral nitrates on all-cause mortality and hospitalization in HFrEF patients using GDMT. Methods and Results: Nitrate prescription at discharge and its association with all-cause mortality and heart failure hospitalization were examined in a propensity-matched analysis of 648 HFrEF patients followed for a median of 56 months. A total of 269 (42%) patients died during that period. In Cox regression analysis, nitrate usage was associated with a slightly increased mortality risk compared with not using nitrates (hazard ratio 1.29; 95% confidence interval 1.01-1.65; P = .040), which continued modestly after the propensity-matched analysis (hazard ratio 1.26; 95% confidence interval 0.95-1.68; P = .102). In both prematch and propensity-matched analyses, nitrate use was not associated with risk of rehospitalization. No significant effect was detected on subgroups stratified by coronary artery disease, age, gender, and background medical therapy. Conclusions: In this study, oral nitrate use alone in addition to GDMT did not affect all-cause mortality and hospitalization risk in HFrEF patients during a long-term follow-up. There was even a modest tendency for increased risk of mortality.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume23
dc.identifier.doi10.1016/j.cardfail.2017.02.006
dc.identifier.eissn1532-8414
dc.identifier.issn1071-9164
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85015945717
dc.identifier.urihttps://doi.org/10.1016/j.cardfail.2017.02.006
dc.identifier.urihttps://hdl.handle.net/20.500.14288/17159
dc.identifier.wos399064300005
dc.keywordsNitrates
dc.keywordsHeart failure
dc.keywordsMortality
dc.language.isoeng
dc.publisherChurchill Livingstone Inc Medical Publishers
dc.relation.ispartofJournal of Cardiac Failure
dc.subjectCardiac and cardiovascular systems
dc.titleEffect of oral nitrates on all-cause mortality and hospitalization in heart failure patients with reduced ejection fraction: a propensity-matched analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorUral, Dilek
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files