Publication: Effect of oral nitrates on all-cause mortality and hospitalization in heart failure patients with reduced ejection fraction: a propensity-matched analysis
dc.contributor.coauthor | Kandemir, Ayşen Şimşek | |
dc.contributor.coauthor | Karaüzüm, Kurtuluş | |
dc.contributor.coauthor | Baydemir, Canan | |
dc.contributor.coauthor | Karaüzüm, İrem Yılmaz | |
dc.contributor.coauthor | Bozyel, Serdar | |
dc.contributor.coauthor | Kozdağ, Güliz | |
dc.contributor.coauthor | Ağır, Ayşen Ağaçdiken | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Ural, Dilek | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-10T00:09:36Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Background: Hydralazine-nitrate combination is recommended for patients with heart failure with reduced ejection fraction (HFrEF)/systolic heart failure who are symptomatic despite guideline-directed medical therapy (GDMT). Use of nitrates alone for this indication is not well-established. This study aims to evaluate the effect of oral nitrates on all-cause mortality and hospitalization in HFrEF patients using GDMT. Methods and Results: Nitrate prescription at discharge and its association with all-cause mortality and heart failure hospitalization were examined in a propensity-matched analysis of 648 HFrEF patients followed for a median of 56 months. A total of 269 (42%) patients died during that period. In Cox regression analysis, nitrate usage was associated with a slightly increased mortality risk compared with not using nitrates (hazard ratio 1.29; 95% confidence interval 1.01-1.65; P = .040), which continued modestly after the propensity-matched analysis (hazard ratio 1.26; 95% confidence interval 0.95-1.68; P = .102). In both prematch and propensity-matched analyses, nitrate use was not associated with risk of rehospitalization. No significant effect was detected on subgroups stratified by coronary artery disease, age, gender, and background medical therapy. Conclusions: In this study, oral nitrate use alone in addition to GDMT did not affect all-cause mortality and hospitalization risk in HFrEF patients during a long-term follow-up. There was even a modest tendency for increased risk of mortality. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 4 | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 23 | |
dc.identifier.doi | 10.1016/j.cardfail.2017.02.006 | |
dc.identifier.eissn | 1532-8414 | |
dc.identifier.issn | 1071-9164 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85015945717 | |
dc.identifier.uri | https://doi.org/10.1016/j.cardfail.2017.02.006 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/17159 | |
dc.identifier.wos | 399064300005 | |
dc.keywords | Nitrates | |
dc.keywords | Heart failure | |
dc.keywords | Mortality | |
dc.language.iso | eng | |
dc.publisher | Churchill Livingstone Inc Medical Publishers | |
dc.relation.ispartof | Journal of Cardiac Failure | |
dc.subject | Cardiac and cardiovascular systems | |
dc.title | Effect of oral nitrates on all-cause mortality and hospitalization in heart failure patients with reduced ejection fraction: a propensity-matched analysis | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Ural, Dilek | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
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