Publication: Predictive value of T2-weighted perfusion and T1-weighted permeability MRI parameters in determining IDH mutational status and grade of gliomas
dc.contributor.coauthor | Karagulle, Mehmet | |
dc.contributor.coauthor | Ozdemir, Merve Sam | |
dc.contributor.coauthor | Mutlu, Samet | |
dc.contributor.coauthor | Kocak, Burak | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.kuauthor | Yüzkan, Sabahattin | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.date.accessioned | 2025-03-06T21:01:12Z | |
dc.date.issued | 2024 | |
dc.description.abstract | AIM: To assess the performance metrics of perfusion and permeability magnetic resonance imaging (MRI) parameters with optimal cut-offs in differentiating isocitrate dehydrogenase (IDH) genotype and tumor grade in patients with grade 2-4 gliomas. MATERIAL and METHODS: This retrospective study included 36 patients surgically diagnosed with grade 2-4 glioma (six grade 2, seven grade 3, and 23 grade 4) with known IDH genotypes (23 IDH wild-type, 13 IDH mutant) between November 2021 and August 2023. All patients underwent preoperative perfusion and permeability MRI examinations with a 3.0 Tesla scanner. Parameters were calculated on colored map images. Using the intraclass correlation coefficient, intra- and inter-observer agreement was assessed. Following multiple testing correction, the perfusion parameters with statistically significant differences were subjected to receiver operating characteristic (ROC) analysis. RESULTS: Five MRI parameters (rCBV and rCBF from perfusion;Ktrans, Ve, and Vp from permeability) showed a significant difference between groups in terms of IDH genotype (p<0.001). In ROC analysis, the best parameters in differentiating IDH genotype included rCBV and Ktrans;rCBV with a cut-off of 5.58 achieved an area under the ROC curve (AUC), sensitivity, specificity, and accuracy of 0.883, 95.7%, 76.9%, and 88.8%, respectively. For Ktrans, with a cut-off of 0.0727 min-1, these values were 0.893, 100%, 69.2%, and 88.8%, respectively. In ROC analysis, these two parameters with rCBF and Ve also showed good performance in differentiating low- and high-grade gliomas with an AUC, sensitivity, and accuracy exceeding 0.940, 86%, and 88%, respectively. CONCLUSION: Perfusion and permeability MRI may provide useful parameters in differentiating the IDH genotype and grade of gliomas | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.publisherscope | National | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.identifier.doi | 10.5137/1019-5149.JTN.46251-24.3 | |
dc.identifier.issn | 1019-5149 | |
dc.identifier.issue | 6 | |
dc.identifier.quartile | Q3 | |
dc.identifier.scopus | 2-s2.0-85209104890 | |
dc.identifier.uri | https://doi.org/10.5137/1019-5149.JTN.46251-24.3 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/27967 | |
dc.identifier.volume | 34 | |
dc.identifier.wos | 1366849800015 | |
dc.keywords | Dynamic contrast-enhanced | |
dc.keywords | Dynamic susceptibility contrast | |
dc.keywords | Glioma grading | |
dc.keywords | Isocitrate dehydrogenase | |
dc.keywords | Magnetic resonance imaging | |
dc.language.iso | eng | |
dc.publisher | Türk Nöroşirürji Derneği | |
dc.relation.ispartof | Turkish Neurosurgery | |
dc.subject | Clinical neurology | |
dc.subject | Surgery | |
dc.title | Predictive value of T2-weighted perfusion and T1-weighted permeability MRI parameters in determining IDH mutational status and grade of gliomas | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Yüzkan, Sabahattin | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
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