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Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats

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dc.contributor.coauthorGök, Müslüm
dc.contributor.coauthorSayın Şakul, Arzu Ayşe
dc.contributor.coauthorArı, Nuray
dc.contributor.coauthorStefek, Milan
dc.contributor.coauthorKarasu, Çimen
dc.contributor.departmentN/A
dc.contributor.kuauthorUlusu, Nuriye Nuray
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid6807
dc.date.accessioned2024-11-09T12:11:11Z
dc.date.issued2017
dc.description.abstractThe pentose phosphate pathway and glutathione-associated metabolism are the main antioxidant cellular defense systems. This study investigated the effects of the powerful antioxidant SMe1EC2 (2-ethoxycarbonyl-8-methoxy-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b] indolinium dichloride) on pentose phosphate pathway (PPP) and glutathione-dependent enzyme activities in aged diabetic and aged matched control rats. Diabetes was induced by streptozotocin injection in rats aged 13–15 months. Diabetic and control rats were divided into two subgroups, one untreated and one treated with SMe1EC2 (10 mg/kg/day, orally) for 4 months. SMe1EC2 ameliorated body weight loss, but not hyperglycemia of aged diabetic rats. Diabetes resulted in decreased glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD) and glutathione-S-transferase (GST), yet in unchanged glutathione reductase (GR) in the liver of aged diabetic rats. In the liver of the aged control rats, SMe1EC2 did not affect
dc.description.fulltextYES
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipVEGA
dc.description.sponsorshipSAS–TÜBİTAK Joint Project
dc.description.sponsorshipAnkara University BAP
dc.description.sponsorshipGazi University BAP
dc.description.versionPublisher version
dc.description.volume10
dc.formatpdf
dc.identifier.doi10.1515/intox-2017-0021
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01471
dc.identifier.linkhttps://doi.org/10.1515/intox-2017-0021
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85043495345
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1020
dc.keywordsSMe1EC2
dc.keywordsAntioxidant
dc.keywordsDiabetes
dc.keywordsAging
dc.keywordsRat
dc.keywordsPentose phosphate pathway
dc.keywordsGlutathione-dependent enzymes
dc.languageEnglish
dc.publisherDe Gruyter
dc.relation.grantno2/0041/15
dc.relation.grantnoJRP 2015/7
dc.relation.grantno10B336002
dc.relation.grantno01/2010-126
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/4480
dc.sourceInterdisciplinary Toxicology
dc.subjectMedicine
dc.subjectMedical biochemistry
dc.titleAntioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-3173-1389
local.contributor.kuauthorUlusu, Nuriye Nuray

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