Publication:
Does Covid-19 infection alter serum biochemical and hematological biomarkers in deceased dementia patients?

dc.contributor.coauthorYucel, Muammer
dc.contributor.coauthorKoseoglu, Mehmet
dc.contributor.departmentKUTTAM (KoƧ University Research Center for Translational Medicine)
dc.contributor.kuauthorUlusu, Nuriye Nuray
dc.contributor.kuauthorAydemir, Duygu
dc.date.accessioned2024-12-29T09:41:31Z
dc.date.issued2024
dc.description.abstractObjectives The elderly population is categorized as a risk group for COVID-19 infection, and dementia is the primary cause of disability in elderly individuals and affects 70 % of the elderly population. In this study, we evaluated the blood and serum biomarkers of deceased dementia patients infected by COVID-19 compared to the survived dementia and non-dementia patients.Methods Laboratory biomarkers of 11 dementia patients infected by COVID-19 have been used for this study. The five patients' serum biochemistry and blood data were compared with the six patients who died because of COVID-19. Additionally, data from nine patients aged 85-96 infected with COVID-19 without dementia have been used to compare the difference between dementia and non-dementia individuals.Results D-dimer, C-reactive protein (CRP), glucose, blood urea nitrogen (BUN), alanine transaminase (ALT), aspartate aminotransferase (AST), troponin, procalcitonin, red cell distribution width (RDW), white blood cell (WBC), neutrophil (NEU) and %NEU levels significantly increased in the deceased dementia patients compared to the survived and non-dementia individuals. Calcium (Ca), hematocrit (HCT), red blood cells (RBC), lymphocyte (%LYM), monocyte %MONO, and basophil (%BASO) levels significantly decreased in the deceased dementia patients compared to the survived and non-dementia individuals infected by COVID-19.Conclusions Serum biochemistry and hematological biomarkers, including D-dimer, CRP, glucose, ALT, AST, BUN, troponin, procalcitonin, RDW, RBC, WBC, NEU, %NEU, Ca, HCT, %LYM, %MONO, and %BASO were significantly altered in deceased dementia patients infected by COVID-19 compared to the survived individuals.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.issue3
dc.description.openaccessgold
dc.description.publisherscopeInternational
dc.description.sponsorsThe authors gratefully acknowledge the use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Head of Strategy and Budget.
dc.description.volume49
dc.identifier.doi10.1515/tjb-2022-0206
dc.identifier.eissn1303-829X
dc.identifier.issn0250-4685
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85203004150
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0206
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23678
dc.identifier.wos1224897400001
dc.keywordsCovid-19
dc.keywordsDementia
dc.keywordsHematological biomarkers
dc.keywordsSerum biochemistry parameters
dc.languageen
dc.publisherWalter de Gruyter GmbH
dc.sourceTurkish Journal of Biochemistry
dc.subjectBiochemistry and molecular biology
dc.titleDoes Covid-19 infection alter serum biochemical and hematological biomarkers in deceased dementia patients?
dc.typeJournal article
dspace.entity.typePublication
local.contributor.kuauthorUlusu, Nuriye Nuray
local.contributor.kuauthorAydemir, Duygu
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Graduate School of Health Sciences
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublication91bbe15d-017f-446b-b102-ce755523d939
relation.isOrgUnitOfPublication.latestForDiscovery91bbe15d-017f-446b-b102-ce755523d939

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
IR04563.pdf
Size:
1.7 MB
Format:
Adobe Portable Document Format