Publication:
Risk factors for acute kidney injury associated with severe hypothyroidism

Placeholder

Departments

School / College / Institute

Organizational Unit

Program

KU-Authors

KU Authors

Co-Authors

Canat, Muhammed Masum
Saygili, Emre S.
Besler, E.
Yildiz, D.
Ozturk, Feyza Yener
Altuntas, Yuksel

Publication Date

Language

Embargo Status

Journal Title

Journal ISSN

Volume Title

Alternative Title

Abstract

Objective. This study aims to investigate the factors affecting development of acute kidney injury (AKI) in patients with severe hypothyroidism. Methods. This retrospective observational study involved patients with primary hypothyroidism and thyroid stimulating hormone (TSH) levels of more than 50 mIU/L at their review in the endocrinology outpatient clinic, between January 2015 and April 2021. Factors affecting the development of AKI were examined by logistic regression analysis. Results. A total of 100 patients, 20 (11 male (M), 9 female (F)) in the AKI (case) group and 80 (23 M, 57 F) patients in control group, were included in our study. The median age of the case group (56 years, interquartile range (IQR) 44.3-68.5) was significantly higher than the control group (49 years, IQR 32.3-60;p = 0.027), and the ratio of males to females was significantly higher in the case group (p = 0.001). Multivariate logistic regression analyses showed that hypothyroidism diagnosed after the age of 60 years (odds ratio (OR) 59.674, 95% confidence intervals (CI) 5.955-598.031;p = 0.001), free triiodothyronine (FT3) < 1.3 pg/mL (OR 17.151, 95% CI 2.491-118.089;p = 0.004) and creatine kinase (CK) > 1000 U/L (OR 1.522, 95% CI 1.602- 82.848;p = 0.015) were predictors for the development of AKI in patients with severe hypothyroidism. Conclusion. We recommend close follow-up and monitoring of patients with AKI caused by severe hypothyroidism if patients who are diagnosed at age > 60 years, CK > 1000 U/L or FT3 < 1.3 pg/mL.

Source

Publisher

EDITURA ACAD ROMANE

Subject

Endocrinology and metabolism

Citation

Has Part

Source

Acta Endocrinologica(Bucharest)

Book Series Title

Edition

DOI

10.4183/aeb.2023.456

item.page.datauri

Link

Rights

Copyrights Note

Endorsement

Review

Supplemented By

Referenced By

0

Views

0

Downloads

View PlumX Details