Publication:
Effect of HBV-HDV co-infection on HBV-HCC co-recurrence in patients undergoing living donor liver transplantation

dc.contributor.coauthorBaskiran, Adil
dc.contributor.coauthorAkbulut, Sami
dc.contributor.coauthorŞahin, Tevfik Tolga
dc.contributor.coauthorKoc, Cemalettin
dc.contributor.coauthorKarakas, Serdar
dc.contributor.coauthorInce, Volkan
dc.contributor.coauthorYılmaz, Sezai
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorYurtaydın, Süleyman Cihan
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.yokid189330
dc.date.accessioned2024-11-09T23:45:19Z
dc.date.issued2020
dc.description.abstractPurpose: To evaluate the effect of hepatitis D virus (HDV) on hepatitis B virus-hepatocellular carcinoma (HBV-HCC) co-recurrence in patients undergoing living donor liver transplantation (LDLT) for HBV alone or HBV-HDV coinfection. Methods: Between 2002 and 2019, 254 HBV-HCC patients underwent LDLT. The patients were divided into two groups after the application of the exclusion criteria: HBV-HCC (Group B; n = 163) and HBV-HDV-HCC (Group D; n = 31). First, the B and D groups were compared in terms of demographic and clinical parameters. Second, patients with (n = 16) and without (n = 178) post-transplant HBV-HCC co-recurrences were grouped and compared in terms of the same parameters. Results: Although the risk of HBV-HCC co-recurrence in group D was 4.99-fold higher than in group B, the risk of HBV recurrence alone in group D was 12.5-fold lower than in group B. The AFP (OR = 4.4), Milan criteria (beyond; OR = 18.8), and HDV (OR = 8.1) were identified as the independent risk factors affecting post-transplant HBV-HCC co-recurrence. The Milan criteria (OR = 2.1) and HBV-HCC co-recurrence (OR = 10.9) were identified as the risk factors affecting post-transplant mortality. HBV-HCC co-recurrence developed in 26.5% of patients in Group B and 100% in Group D (OR = 40; p = 0.001). HCC recurrence alone developed in 10% of patients without HBV recurrence in group B and 0% of patients without HBV recurrence in group D (OR = 5.7). Conclusion: This study showed that the risk of HBV recurrence alone was reduced by 12.5-fold in the presence of HDV; however, the HCC recurrence occurred in all patients with HDV when HBV recurrence developed.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.volume14
dc.identifier.doi10.1007/s12072-020-10085-3
dc.identifier.eissn1936-0541
dc.identifier.issn1936-0533
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85090305845
dc.identifier.urihttp://dx.doi.org/10.1007/s12072-020-10085-3
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13814
dc.identifier.wos566873000001
dc.keywordsLiver transplantation
dc.keywordsHCC
dc.keywordsHBV
dc.keywordsHDV
dc.keywordsHBV recurrence alone
dc.keywordsHCC recurrence alone
dc.keywordsHBV-HCC co-recurrence
dc.keywordsHepatitis-B
dc.keywordsHepatocellular-carcinoma
dc.keywordsDelta-hepatitis
dc.keywordsVirus-infection
dc.keywordsCirrhosis
dc.keywordsDNA
dc.languageEnglish
dc.publisherSpringer
dc.sourceHepatology International
dc.subjectGastroenterology
dc.subjectHepatology
dc.titleEffect of HBV-HDV co-infection on HBV-HCC co-recurrence in patients undergoing living donor liver transplantation
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-5419-7158
local.contributor.kuauthorYurtaydın, Süleyman Cihan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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