Publication:
Multiomics analysis reveals the impact of microbiota on host metabolism in hepatic steatosis

dc.contributor.coauthorArif, Muhammad
dc.contributor.coauthorLi, Xiangyu
dc.contributor.coauthorAltay, Özlem
dc.contributor.coauthorShi, Mengnan
dc.contributor.coauthorShoaie, Saeed
dc.contributor.coauthorTürkez, Hasan
dc.contributor.coauthorNielsen, Jens
dc.contributor.coauthorZhang, Cheng
dc.contributor.coauthorUhlen, Mathias
dc.contributor.coauthorBoren, Jan
dc.contributor.coauthorMardinoğlu, Adil
dc.contributor.coauthorYang, Hong
dc.contributor.kuauthorUral, Dilek
dc.contributor.kuauthorAkyıldız, Murat
dc.contributor.kuauthorGönenli, Mehmet Gökhan
dc.contributor.kuauthorKurtoğlu, Burçin Sağlam
dc.contributor.kuauthorYiğit Alpdoğan, Buket
dc.contributor.kuauthorUlukan, Bürge
dc.contributor.kuauthorZeybel, Müjdat
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileTeaching Faculty
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteGraduate School of Health Sciences
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid1057
dc.contributor.yokid123080
dc.contributor.yokid350445
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.date.accessioned2024-11-09T12:18:48Z
dc.date.issued2022
dc.description.abstractMetabolic dysfunction-associated fatty liver disease (MAFLD) is a complex disease involving alterations in multiple biological processes regulated by the interactions between obesity, genetic background, and environmental factors including the microbiome. To decipher hepatic steatosis (HS) pathogenesis by excluding critical confounding factors including genetic variants and diabetes, 56 heterogenous MAFLD patients are characterized by generating multiomics data including oral and gut metagenomics as well as plasma metabolomics and inflammatory proteomics data. The dysbiosis in the oral and gut microbiome is explored and the host-microbiome interactions based on global metabolic and inflammatory processes are revealed. These multiomics data are integrated using the biological network and HS's key features are identified using multiomics data. HS is finally predicted using these key features and findings are validated in a follow-up cohort, where 22 subjects with varying degree of HS are characterized.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyPubMed
dc.description.issue11
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipKnut and Alice Wallenberg Foundation
dc.description.sponsorshipScandiBio Therapeutics
dc.description.sponsorshipEuropean Union (EU)
dc.description.sponsorshipHorizon 2020
dc.description.sponsorshipPoLiMeR Innovative Training Network
dc.description.sponsorshipMarie Sklodowska-Curie Grant
dc.description.sponsorshipResearch and Innovation Program
dc.description.sponsorshipUppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX)
dc.description.versionPublisher version
dc.description.volume9
dc.formatpdf
dc.identifier.doi10.1002/advs.202104373
dc.identifier.eissn2198-3844
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03545
dc.identifier.linkhttps://doi.org/10.1002/advs.202104373
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85124490358
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1471
dc.identifier.wos751803900001
dc.keywordsGut and oral metagenomics
dc.keywordsMetabolic dysfunction-associated fatty liver disease
dc.keywordsMetabolomics
dc.keywordsMultiomics analysis
dc.keywordsProteomics
dc.keywordsSystems biology
dc.keywordsSystems medicine
dc.languageEnglish
dc.publisherWiley
dc.relation.grantno812616
dc.relation.grantnosens2019031
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10405
dc.sourceAdvanced Science
dc.subjectMultidisciplinary chemistry
dc.subjectNanoscience and nanotechnology
dc.subjectMultidisciplinary materials science
dc.titleMultiomics analysis reveals the impact of microbiota on host metabolism in hepatic steatosis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0001-6419-0323
local.contributor.authorid0000-0002-2080-7528
local.contributor.authorid0000-0003-2925-7048
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.kuauthorUral, Dilek
local.contributor.kuauthorAkyıldız, Murat
local.contributor.kuauthorGönenli, Mehmet Gökhan
local.contributor.kuauthorKurtoğlu, Burçin Sağlam
local.contributor.kuauthorYiğit Alpdoğan, Buket
local.contributor.kuauthorUlukan, Bürge
local.contributor.kuauthorZeybel, Müjdat

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