Publication:
Liquid plug formation in an airway closure model

dc.contributor.coauthorRomano, Francesco
dc.contributor.coauthorFujioka, Hiroshi
dc.contributor.coauthorGrotberg, James B.
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.kuauthorMuradoğlu, Metin
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T11:48:47Z
dc.date.issued2019
dc.description.abstractThe closure of a human lung airway is modeled as an instability of a two-phase flow in a pipe coated internally with a Newtonian liquid. For a thick enough coating, the Plateau-Rayleigh instability creates a liquid plug which blocks the airway, halting distal gas exchange. Owing to a bifrontal plug growth, this airway closure flow induces high stress levels on the wall, which is the location of airway epithelial cells. A parametric numerical study is carried out simulating relevant conditions for human lungs, in either ordinary or pathological situations. Our simulations can represent the physical process from pre- to postcoalescence phases. Previous studies have been limited to precoalescence only. The topological change during coalescence induces a high level of stress and stress gradients on the epithelial cells, which are large enough to damage them, causing sublethal or lethal responses. We find that postcoalescence wall stresses can be in the range of 300% to 600% greater than precoalescence values and so introduce an important source of mechanical perturbation to the cells.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue9
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipNational Institutes of Health (NIH)
dc.description.versionAuthor's final manuscript
dc.description.volume4
dc.identifier.doi10.1103/PhysRevFluids.4.093103
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01955
dc.identifier.issn2469-990X
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85072917306
dc.identifier.urihttps://hdl.handle.net/20.500.14288/621
dc.identifier.wos488273200001
dc.keywordsFluid-elastic instabilities
dc.keywordsCapillary instability
dc.keywordsRayleigh instability
dc.keywordsPulmonary surfactant
dc.keywordsFlow-fields
dc.keywordsPropagation
dc.keywordsstability
dc.keywordsMechanics
dc.keywordsRupture
dc.keywordsBreakup
dc.language.isoeng
dc.publisherAmerican Physical Society (APS)
dc.relation.grantnoR01-HL136141
dc.relation.ispartofPhysical Review Fluids
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8503
dc.subjectPhysics
dc.subjectFluids and plasmas
dc.titleLiquid plug formation in an airway closure model
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorMuradoğlu, Metin
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Mechanical Engineering
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