Publication:
NEUROD2 regulates stim1 expression and store-operated calcium entry in cortical neurons

dc.contributor.coauthorN/A
dc.contributor.departmentDepartment of Molecular Biology and Genetics
dc.contributor.departmentDepartment of Physics
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorAkkaya, Cansu
dc.contributor.kuauthorBayam, Efil
dc.contributor.kuauthorDunn, Gülayşe İnce
dc.contributor.kuauthorGüner, Gökhan
dc.contributor.kuauthorGüzelsoy, Gizem
dc.contributor.kuauthorİşleyen, Fatma Sadife
dc.contributor.kuauthorKabakçıoğlu, Alkan
dc.contributor.kuauthorKotan, Ilgın Eser
dc.contributor.kuauthorŞahin, Gülcan Semra
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2024-11-09T22:57:25Z
dc.date.issued2017
dc.description.abstractCalcium signaling controls many key processes in neurons, including gene expression, axon guidance, and synaptic plasticity. In contrast to calcium influx through voltage- or neurotransmitter-gated channels, regulatory pathways that control store-operated calcium entry (SOCE) in neurons are poorly understood. Here, we report a transcriptional control of Stim1 (stromal interaction molecule 1) gene, which is a major sensor of endoplasmic reticulum (ER) calcium levels and a regulator of SOCE. By using a genome-wide chromatin immunoprecipitation and sequencing approach in mice, we find that NEUROD2, a neurogenic transcription factor, binds to an intronic element within the Stim1 gene. We show that NEUROD2 limits Stim1 expression in cortical neurons and consequently fine-tunes the SOCE response upon depletion of ER calcium. Our findings reveal a novel mechanism that regulates neuronal calcium homeostasis during cortical development.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipEuropean Commission FP7 International Reintegration Grant [PIRG07-GA-2010-268433]
dc.description.sponsorshipTurkish Academy of Sciences Young Scientist Program (TUBA-GEBIP)
dc.description.sponsorshipKoc University, Istanbul, Turkey The work was funded by following grants to G.I.-D.: European Commission FP7 International Reintegration Grant PIRG07-GA-2010-268433
dc.description.sponsorshipTurkish Academy of Sciences Young Scientist Program (TUBA-GEBIP)
dc.description.sponsorshipand Koc University, Istanbul, Turkey.
dc.description.volume4
dc.identifier.doi10.1523/ENEURO.0255-16.2017
dc.identifier.eissn2373-2822
dc.identifier.scopus2-s2.0-85031920627
dc.identifier.urihttps://doi.org/10.1523/ENEURO.0255-16.2017
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7550
dc.identifier.wos403354100014
dc.keywordsCalcium
dc.keywordsGenomics
dc.keywordsNeurod2
dc.keywordsStore-operated calcium entry
dc.keywordsTranscription factor
dc.keywordsNeural progenitor cells
dc.keywordsCentral-nervous-system
dc.keywordsBrain-development
dc.keywordsCerebral-Cortex
dc.keywordsTranscriptional activation
dc.keywordsNeocortical development
dc.keywordsGene-expression
dc.keywordsBhlh Proteins
dc.keywordsOrai proteins
dc.keywordsCrac channels
dc.language.isoeng
dc.publisherSoc Neuroscience
dc.relation.ispartofEneuro
dc.subjectNeurosciences
dc.titleNEUROD2 regulates stim1 expression and store-operated calcium entry in cortical neurons
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGüner, Gökhan
local.contributor.kuauthorGüzelsoy, Gizem
local.contributor.kuauthorİşleyen, Fatma Sadife
local.contributor.kuauthorŞahin, Gülcan Semra
local.contributor.kuauthorAkkaya, Cansu
local.contributor.kuauthorBayam, Efil
local.contributor.kuauthorKotan, Ilgın Eser
local.contributor.kuauthorKabakçıoğlu, Alkan
local.contributor.kuauthorDunn, Gülayşe İnce
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Sciences
local.publication.orgunit2Department of Physics
local.publication.orgunit2Department of Molecular Biology and Genetics
local.publication.orgunit2Graduate School of Sciences and Engineering
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