Publication:
Acute kidney injury in hospitalized COVID-19 patients

dc.contributor.coauthorMedetalibeyoğlu, Alpay
dc.contributor.coauthorKanbay, Asiye
dc.contributor.coauthorNaci
dc.contributor.coauthorKonyaoğlu, Hilal
dc.contributor.coauthorAkpınar, Timur S.
dc.contributor.coauthorKöse, Murat
dc.contributor.coauthorCovic, Adrian
dc.contributor.coauthorTükek, Tufan
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBaygül, Arzu Eden
dc.contributor.kuauthorÇevik, Enes
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorTanrıöver, Cem
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:29:43Z
dc.date.issued2022
dc.description.abstractBackground: Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in hospitalized patients are not well studied. Materials and methods:  This is a retrospective cohort study conducted in two major university hospitals. Electronic health records of the patients, 18 years or older, hospitalized between 13 April and 1 June 2020 with confirmed COVID-19 were reviewed. We described the incidence and the risk factors for AKI development in COVID-19 patients. Furthermore, we investigated the effects of AKI on the length of hospital and intensive care unit (ICU) stay, the admission rates to ICU, the percentage of patients with cytokine storm and in-hospital mortality rate. Results: Among 770 hospitalized patients included in this study, 92 (11.9%) patients developed AKI. The length of hospitalized days (16 vs 9.9, p < 0.001) and days spent in the hospital until ICU admission (3.5 vs. 2.5, p = 0.003) were higher in the AKI group compared to patients without AKI. In addition, ICU admission rates were also significantly higher in patients with AKI (63% vs. 20.7%, p < 0.001). The percentage of patients with AKI who developed cytokine storm was significantly higher than patients without AKI (25.9% vs. 14%, p = 0.009). Furthermore, the in-hospital mortality rate was significantly higher in patients with AKI (47.2% vs. 4.7%, p < 0.001). Conclusions: AKI is common in hospitalized COVID-19 patients. Furthermore, we show that AKI increases the admission rates to ICU and in-hospital mortality. Our findings suggest that AKI should be effectively managed to prevent the adverse outcomes in COVID-19 patients.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue5
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume54
dc.identifier.doi10.1007/s11255-021-02972-x
dc.identifier.eissn1573-2584
dc.identifier.issn0301-1623
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85112808078
dc.identifier.urihttps://doi.org/10.1007/s11255-021-02972-x
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12107
dc.identifier.wos686476100001
dc.keywordsCOVID-19
dc.keywordsAcute kidney injury
dc.keywordsHospital stay
dc.keywordsMortality
dc.language.isoeng
dc.relation.ispartofInternational Urology and Nephrology
dc.subjectUrology
dc.subjectNephrology
dc.titleAcute kidney injury in hospitalized COVID-19 patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorÇevik, Enes
local.contributor.kuauthorTanrıöver, Cem
local.contributor.kuauthorBaygül, Arzu Eden
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
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