Publication: Interval timing deficits and their neurobiological correlates in aging mice
Program
School College Institute
GRADUATE SCHOOL OF SOCIAL SCIENCES AND HUMANITIES
College of Social Sciences and Humanities
Research Center
College of Social Sciences and Humanities
Research Center
KU-Authors
KU Authors
Co-Authors
Arkan, Sertan
Karson, Ayşe
Advisor
Publication Date
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Embargo Status
Journal Title
Journal ISSN
Volume Title
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Abstract
Age-related neurobiological and cognitive alterations suggest that interval timing (as a related function) is also altered in aging, which can, in turn, disrupt timing-dependent functions. We investigated alterations in interval timing with aging and accompanying neurobiological changes. We tested 4-6, 10-12, and 18-20 month-old mice on the dual peak interval procedure. Results revealed a specific deficit in the termination of timed responses (stop-times). The decision processes contributed more to timing variability (vs. clock/memory process) in the aged mice. We observed age-dependent reductions in the number of dopaminergic neurons in the VTA and SNc, cholinergic neurons in the medial septum/diagonal band (MS/DB) complex, and density of dopaminergic axon terminals in the DLS/DMS. Negative correlations were found between the number of dopaminergic neurons in the VTA and stop times, and the number of cholinergic neurons in MS/DB complex and the acquisition of stop times. Our results point at age-dependent changes in the decisional components of interval timing and the role of dopaminergic and cholinergic functions in these behavioral alterations. (C) 2020 Elsevier Inc. All rights reserved.
Source:
Publisher:
Elsevier Science Inc
Subject
Geriatrics, Gerontology, Neurosciences
Citation
Has Part
Source:
Neurobiology of Aging
Book Series Title
Edition
DOI
10.1016/j.neurobiolaging.2020.02.021