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Emerging role of the ubiquitin-proteasome system as drug targets

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dc.contributor.coauthorFraternali, Franca
dc.contributor.departmentDepartment of Computer Engineering
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentCCBB (The Center for Computational Biology and Bioinformatics)
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorGürsoy, Attila
dc.contributor.kuauthorKeskin, Özlem
dc.contributor.kuauthorMakinacı, Gözde Kar
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T23:42:32Z
dc.date.issued2013
dc.description.abstractThe ubiquitin-proteosome system (UPS) regulates a wide range of cellular processes including protein degradation, DNA repair, transcription regulation, and cell signaling. Alterations and mutations in UPS components give rise to various human diseases, most prominently cancer and neurodegenerative disorders. Here, we review recent advances in UPS-based drug discovery highlighting the emerging relationships between the UPS and disease and discuss potential future therapeutic interventions. In particular, we focus on recent structural approaches in UPS and explain how the knowledge of protein structural details can guide the design of specifically targeted inhibitors.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue18
dc.description.openaccessNO
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipTUBITAK [109T343] This work has been supported by TUBITAK (Research Grant Number: 109T343).
dc.description.volume19
dc.identifier.doi10.2174/1381612811319180002
dc.identifier.issn1381-6128
dc.identifier.scopus2-s2.0-84878887472
dc.identifier.urihttps://doi.org/10.2174/1381612811319180002
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13340
dc.identifier.wos318156100002
dc.keywordsUbiquitin-proteosome system
dc.keywordsSisease
dc.keywordsDrug design
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Design
dc.subjectPharmacology
dc.subjectPharmacy
dc.titleEmerging role of the ubiquitin-proteasome system as drug targets
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKeskin, Özlem
local.contributor.kuauthorKar, Gözde
local.contributor.kuauthorGürsoy, Attila
local.publication.orgunit1College of Engineering
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Chemical and Biological Engineering
local.publication.orgunit2Department of Computer Engineering
local.publication.orgunit2CCBB (The Center for Computational Biology and Bioinformatics)
local.publication.orgunit2Graduate School of Sciences and Engineering
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