Publication:
Long-term prophylactic transcranial direct current stimulation ameliorates allodynia and improves clinical outcomes in individuals with migraine

dc.contributor.coauthorAksu, Serkan
dc.contributor.coauthorŞirin, Tuba Cerrahoğlu
dc.contributor.coauthorHasırcı Bayır, Buse Rahime
dc.contributor.coauthorUlukan, Çağrı
dc.contributor.coauthorSoyata, Ahmet Zihni
dc.contributor.coauthorKurt, Adnan
dc.contributor.coauthorBaykan, Betül
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKaramürsel, Sacit
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:56:30Z
dc.date.issued2022
dc.description.abstractObjectives: Migraine is a common and substantially debilitating disorder that may associate with allodynia, a marker of central sensitization in the pain circuits. Several unmet needs, like limited adherence to drugs due to adverse events and cost-effectivity, still occur in the prophylactic treatment of migraine. Transcranial direct current stimulation (tDCS) has recently been indicated to be beneficial in individuals with migraine with and without allodynia. However, to our knowledge, there are no studies evaluating the efficacy of six-month tDCS in migraine. Materials and Methods: This study was a randomized double-blind parallel-group sham-controlled five-month extension study after a one-month lead-in trial of tDCS in individuals with migraine. A total of 23 individuals with migraine with allodynia who completed the lead-in trial were recruited after their consent and were administered three consecutive sessions of 2-mA anodal 20-minute tDCS over the left primary motor cortex every month for an additional five months. Pain-related outcomes were determined using monthly headache diaries. Allodynia, depression, anxiety, and disability because of migraine also were assessed throughout the study. Results: Improvements in allodynia levels, attack frequency, number of rescue medications, and attack duration were higher, and mostly gradual during the trial, in the active group. Migraine Disability Scale grades also were lower in the active group, whereas no between-group differences were found in depression and anxiety scores. Higher responder rates of migraine attack frequency (56.8% vs 25%), number of headache days (56% vs 16.7%), and migraine attack duration (90.9% vs 8.3%) were observed after six-month tDCS in the active group than in the sham group. Conclusions: Long-term extended tDCS is shown to be a safe, efficacious, and plausible modality for prophylactic treatment in individuals with migraine with allodynia. Significance: Long-term extended tDCS can alleviate allodynia, which is an indicator of drug resistance and chronicity, and meet the goals of prophylactic treatment in individuals with migraine with allodynia.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipSource(s) of financial support: The lead-in trial was financially supported by the Scientific Research Projects Coordination Unit of Istanbul University (TYL/2019-33704). No additional financial support was taken for the extension trial.
dc.identifier.doi10.1016/j.neurom.2022.06.007
dc.identifier.issn1094-7159
dc.identifier.scopus2-s2.0-85136766220
dc.identifier.urihttps://doi.org/10.1016/j.neurom.2022.06.007
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7371
dc.identifier.wos1060025800001
dc.keywordsAllodynia
dc.keywordsMigraine
dc.keywordsMigraine prophylaxis
dc.keywordsNoninvasive brain stimulation
dc.keywordsTranscranial direct current stimulation
dc.language.isoeng
dc.publisherInternational Neuromodulation Society
dc.relation.ispartofNeuromodulation
dc.subjectMedicine
dc.subjectTranscranial direct current stimulation
dc.subjectStimulation
dc.subjectMotor cortex
dc.titleLong-term prophylactic transcranial direct current stimulation ameliorates allodynia and improves clinical outcomes in individuals with migraine
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKaramürsel, Sacit
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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