Publication:
Thalamo-Insular cortex connections in the rat and human

dc.contributor.coauthorOzkan,Mazhar
dc.contributor.coauthorGunes,Yasin Celal
dc.contributor.coauthorAlgin,Oktay
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorAltınöz, Damlasu
dc.contributor.kuauthorErkan, Elif
dc.contributor.kuauthorÇavdar, Safiye
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:59:46Z
dc.date.issued2024
dc.description.abstractThe insular cortex (ICx) has a role in large a variety of functions. Thalamus plays an important role in modulating cortical functions. The present study aims to show thalamic-ICx connections using the fluoro-gold (FG) tracing method in rats and diffusion tensoring-based tractography (DTI) in humans. Wistar albino rats were pressure injected with the FG tracer into the anterior and posterior ICx. The DTI data were obtained from the Human Connectome Project database. Our findings showed that the thalamic-ICx connections were strictly ipsilateral in the rat, however, bilateral connections were present in humans. The anterior ICx was connected to the paraventricular, centromedial, paracentral, centrolateral, ventral posteromedial, and medial geniculate thalamic nuclei. The posterior ICx was connected to the centromedian, parafasicular, renuence, lateral, posterior, ventral posteromedial, and medial geniculate thalamic nuclei. The DTI in humans corresponded with the results of the experimental study on rats. The results of the current study may provide an understanding of how thalamic nuclei may contribute to higher-order ICx functions. The ipsilateral connections in the rat and bilateral in humans may provide insights into anatomical evolution and functional differences of the ICx circuit in humans and rats. Further, stimulation of the thalamus can be a potential target for treating or modulating ICx functions such as anxiety, depression, and certain chronic pain conditions.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1016/j.neulet.2024.138111
dc.identifier.issn0304-3940
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85214117529
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2024.138111
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27760
dc.identifier.volume847
dc.identifier.wos1402665600001
dc.keywordsInsular cortex
dc.keywordsThalamus
dc.keywordsTractography
dc.keywordsFluoro-gold tracer
dc.keywordsConnections
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.subjectMedicine
dc.titleThalamo-Insular cortex connections in the rat and human
dc.typeJournal Article
dspace.entity.typePublication
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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