Publication:
Amnioinfusion vs. standard management for the second trimester PPROM: a systematic review and meta-analysis of observational studies and RCTs

dc.contributor.coauthorAyhan, Isil
dc.contributor.coauthorMelekoglu, Rauf
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÜnal, Ceren
dc.contributor.kuauthorYıldız, Abdullah Burak
dc.contributor.kuauthorÇekiç, Sebile Güler
dc.contributor.kuauthorÇelik, Ebru
dc.contributor.kuauthorGürsoy, Tuğba
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:29:43Z
dc.date.issued2023
dc.description.abstractObjective This meta-analysis aims to review the effect of serial transabdominal amnioinfusion (TAI) on short-term and long-term perinatal outcomes in mid-trimester preterm premature rupture of membranes (PPROM). Methods Literature searches of PubMed, Web of Sciences, Scopus, and Cochrane Library were performed from their inception to April 2022. Studies comparing conventional treatment with serial TAI in women with proven PPROM at less than 26 + 0 weeks of gestation with oligohydramnios were included. Studies that included oligohydramnios due to other reasons such as fetal growth retardation or renal anomalies were excluded. Risk of bias in observational studies was assessed using the tool of the Cochrane Review group identified as risk of bias in non-randomized studies - of interventions. The risk of bias assessments for RCTs were performed according to the Cochrane risk-of-bias tool for randomized trials. An I (2) score was used to assess the heterogeneity of included studies. The analyses were performed by using random-effect model, and the results were expressed as relative risk (RR) or mean difference with 95% confidence intervals (CIs). Results Overall, eight relevant studies including five observational studies (n = 252; 130 women allocated to the intervention) and three RCTs (n = 183; 93 women allocated to the intervention) were eligible. The pooled latency period was 21.9 days (95% CI, 13.1-30.8) and 5.8 days (95% CI, -11.6-23.2) longer in the TAI group in the observational studies and RCTs, respectively. The perinatal mortality rate reduced in the intervention group when tested in observational studies (RR 0.68; 95% CI, 0.51-0.92), but not in RCTs (RR 0.79; 95% CI, 0.56-1.13). The rate of long-term healthy survival was higher in the children whose mothers were treated with the TAI (35.7%) than those were treated with the standard management (28.6%) (RR 1.30, 95% CI 0.47-3.60, "best case scenario"). Conclusions The efficacy of serial TA on early PPROM associated morbidity and mortality is not attested. Additional randomized control trials with adequate power are needed.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccesshybrid
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipWe appreciated the work of Ertac Nebioglu who an expertise librarian is. The review was registered with PROSPERO (CRD42021262620).
dc.description.volume36
dc.identifier.doi10.1080/14767058.2023.2230511
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85163955093
dc.identifier.urihttps://doi.org/10.1080/14767058.2023.2230511
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25937
dc.identifier.wos1022646900001
dc.keywordsPPROM
dc.keywordsAmnioinfusion
dc.keywordsOligohydramnios
dc.keywordsPerinatal mortality
dc.keywordsHealthy survival
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.grantnoErtac Nebioglu
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicine
dc.subjectObstetrics and gynecology
dc.titleAmnioinfusion vs. standard management for the second trimester PPROM: a systematic review and meta-analysis of observational studies and RCTs
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorÇelik, Ebru
local.contributor.kuauthorYıldız, Abdullah Burak
local.contributor.kuauthorÇekiç, Sebile Güler
local.contributor.kuauthorÜnal, Ceren
local.contributor.kuauthorGürsoy, Tuğba
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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