Publication:
Treatment patterns and outcomes in patients with chronic urticaria during pregnancy: results of PREG-CU, a UCARE study

dc.contributor.coauthorAl-Ahmad, Mona
dc.contributor.coauthorKrause, Karoline
dc.contributor.coauthorGimenez-Arnau, Ana M.
dc.contributor.coauthorThomsen, Simon Francis
dc.contributor.coauthorConlon, Niall
dc.contributor.coauthorMarsland, Alexander
dc.contributor.coauthorŞavk, Ekin
dc.contributor.coauthorCriado, Roberta F.
dc.contributor.coauthorDanilycheva, Inna
dc.contributor.coauthorFomina, Daria
dc.contributor.coauthorGodse, Kiran
dc.contributor.coauthorKhoshkhui, Maryam
dc.contributor.coauthorDeğirmentepe, Ece Nur
dc.contributor.coauthorDemir, Semra
dc.contributor.coauthorEnsina, Luis Felipe
dc.contributor.coauthorKasperska-Zajac, Alicja
dc.contributor.coauthorRudenko, Michael
dc.contributor.coauthorValle, Solange
dc.contributor.coauthorMedina, Iris
dc.contributor.coauthorBauer, Andrea
dc.contributor.coauthorZhao, Zuotao
dc.contributor.coauthorStaubach, Petra
dc.contributor.coauthorBouillet, Laurence
dc.contributor.coauthorKüçük, Özlem Su
dc.contributor.coauthorMaurer, Marcus
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBaygül, Arzu Eden
dc.contributor.kuauthorKocatürk Göncü, Özgür Emek
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:11:11Z
dc.description.abstractBackground: although chronic urticaria (CU) is a common and primarily affects females, there is little data on how pregnancy interacts with the disease. Objective: to analyse the treatment use by CU patients before, during and after pregnancy as well as outcomes of pregnancy. Methods: PREG-CU is an international, multicentre study of the Urticaria Centers of Reference and Excellence network. Data were collected via a 47-item-questionnaire completed by CU patients who became pregnant during their disease course. Results: questionnaires from 288 CU patients from 13 countries were analysed. During pregnancy, most patients (60%) used urticaria medication including standard-dose second generation H1-antihistamines (35.1%), first generation H1-antihistamines (7.6%), high-dose second-generation H1-antihistamines (5.6%) and omalizumab (5.6%). The preterm birth rate was 10.2%; rates were similar between patients who did and did not receive treatment during pregnancy (11.6% vs. 8.7%, respectively). Emergency referrals for CU and twin birth were risk factors for preterm birth. The caesarean delivery rate was 51.3%. More than 90% of new-borns were healthy at birth. There was no link between any patient or disease characteristics or treatments and medical problems at birth. Conclusion: most CU patients used treatment during pregnancy especially second-generation antihistamines which seem to be safe during pregnancy regardless of the trimester. The rates of preterm births and medical problems of new-borns in CU patients were similar to population norms and not linked to treatment used during pregnancy. Emergency referrals for CU increased the risk of preterm birth and emphasize the importance of sufficient treatment to keep urticaria under control during pregnancy.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThe authors wish to thank the patients for their participation in this study. In addition, Leonard Lionnet, PhD providedmedical writing assistance which was funded by UCARE (www.ga2len--ucare.com). Open Access funding enabled and organized by Projekt DEAL.
dc.description.versionPublisher version
dc.description.volume37
dc.identifier.doi10.1111/jdv.18574
dc.identifier.eissn1468-3083
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03999
dc.identifier.issn0926-9959
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85138194304
dc.identifier.urihttps://doi.org/10.1111/jdv.18574
dc.identifier.wos854413600001
dc.language.isoeng
dc.publisherWiley
dc.relation.grantnoNA
dc.relation.ispartofJournal of the European Academy of Dermatology And Venereology
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10873
dc.subjectChronic disease
dc.subjectFemale
dc.subjectHistamine H1 antagonists
dc.subjectTherapeutic use
dc.subjectInfant, Newborn
dc.subjectOmalizumab
dc.subjectPregnancy
dc.subjectUrticaria
dc.subjectDrug therapy
dc.subjectEpidemiology
dc.titleTreatment patterns and outcomes in patients with chronic urticaria during pregnancy: results of PREG-CU, a UCARE study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKocatürk Göncü, Özgür Emek
local.contributor.kuauthorBaygül, Arzu Eden
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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