Publication:
The impact of Substantial LYMphovascular space invasion on sentinel lymph nodes status and recurrence in Endometrial Cancer patients: SLYM-EC a multicenter retrospective study

dc.contributor.coauthorBuda, Alessandro
dc.contributor.coauthorFruscio, Robert
dc.contributor.coauthorMauro, Jessica
dc.contributor.coauthorImboden, Sara
dc.contributor.coauthorDe Ponti, Elena
dc.contributor.coauthorPerrone, Emanuele
dc.contributor.coauthorGrassi, Tommaso
dc.contributor.coauthorBruno, Valentina
dc.contributor.coauthorGarcia-Pineda, Virginia
dc.contributor.coauthorTaskini, Salih
dc.contributor.coauthorRestainoj, Stefano
dc.contributor.coauthorSiegenthaler, Franziska
dc.contributor.coauthorCasarin, Jvan
dc.contributor.coauthorRaimondo, Diego
dc.contributor.coauthorCapozzi, Vito Andrea
dc.contributor.coauthorVatansever, Dogan
dc.contributor.coauthorCapasso, Ilaria
dc.contributor.coauthorVizza, Enrico
dc.contributor.coauthorGungor, Mete
dc.contributor.coauthorZapardiel, Ignacio
dc.contributor.coauthorPapadia, Andrea
dc.contributor.coauthorFanfani, Francesco
dc.contributor.coauthorVizzielli, Giuseppe
dc.contributor.coauthorScambia, Giovanni
dc.contributor.coauthorMuellerd, Michael
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTaşkıran, Çağatay
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:58:06Z
dc.date.issued2024
dc.description.abstractIntroduction: To evaluate the prognostic impact of substantial lymph vascular space invasion (LVSI) on the sentinel lymph node involvement and recurrence rate of patients with apparent uterine-confined endometrial cancer. Materials and methods: We enrolled consecutive patients with apparent confined endometrial cancer who underwent surgical staging with sentinel node mapping from 14 European reference centers. LVSI was analyzed semi-quantitatively, according to a 3-tiered scoring system classified as absent, focal, and substantial. Results: Among 2352 eligible patients, 1980 were included in the analysis. Upon final pathology 226 patients (11.4 %) had SLNs involvement. LVSI was diagnosed focal in 152 patients (7.7 %), whereas 357 patients (18.0 %) showed substantial LVSI. Focal or substantial LVSI rate were significantly higher in patients with positive SLNs when compared to patients without SLNs involvement (p < 0.0001). On overall patient-based analysis, the sensitivity, specificity, positive predictive value, and negative predictive value of LVSI for sentinel lymph node metastases were 73 %, 80 %, 32 %, and 96 %, respectively. The 3-year multivariate analysis of recurrence-free survival showed that only the presence of substantial LVSI, and grade 3 disease were associated with relapse. Neither positive sentinel lymph node, deep myometrial infiltration, nor age at surgery were statistically significant.<br /> Conclusions: In patients having undergone sentinel node biopsy, positive LVSI demonstrated moderate sensitivity and reasonable specificity in detecting SLN involvement. LVSI positivity does not correlate with nodal involvement. The presence of substantial LVSI remains a strong independent risk factor for recurrence, indicating a role for potential hematogenous dissemination in patients with early-stage disease.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1016/j.ejso.2024.108731
dc.identifier.eissn1532-2157
dc.identifier.issn0748-7983
dc.identifier.issue12
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85206267114
dc.identifier.urihttps://doi.org/10.1016/j.ejso.2024.108731
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27369
dc.identifier.volume50
dc.identifier.wos1340426800001
dc.keywordsEndometrial cancer
dc.keywordsSubstantial lvsi
dc.keywordsSentinel node biopsy
dc.keywordsRecurrence-free survival
dc.language.isoeng
dc.publisherElsevier Science Ltd
dc.relation.ispartofEJSO
dc.subjectOncology
dc.subjectSurgery
dc.titleThe impact of Substantial LYMphovascular space invasion on sentinel lymph nodes status and recurrence in Endometrial Cancer patients: SLYM-EC a multicenter retrospective study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTaşkıran, Çağatay
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
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