Publication: Comprehensive characterization of intraductal oncocytic papillary neoplasm of the pancreas: a systematic and critical review
dc.contributor.coauthor | Paolino, Gaetano | |
dc.contributor.coauthor | Basturk, Olca | |
dc.contributor.coauthor | Esposito, Irene | |
dc.contributor.coauthor | Hong, Seung-Mo | |
dc.contributor.coauthor | Brosens, Lodewijk A. | |
dc.contributor.coauthor | Tarcan, Zeynep | |
dc.contributor.coauthor | Wood, Laura D. | |
dc.contributor.coauthor | Gkountakos, Anastasios | |
dc.contributor.coauthor | Omori, Yuko | |
dc.contributor.coauthor | Mattiolo, Paola | |
dc.contributor.coauthor | Ciulla, Calogero | |
dc.contributor.coauthor | Marchegiani, Giovanni | |
dc.contributor.coauthor | Pea, Antonio | |
dc.contributor.coauthor | Bevere, Michele | |
dc.contributor.coauthor | De Robertis, Riccardo | |
dc.contributor.coauthor | D'Onofrio, Mirko | |
dc.contributor.coauthor | Salvia, Roberto | |
dc.contributor.coauthor | Cheng, Liang | |
dc.contributor.coauthor | Furukawa, Toru | |
dc.contributor.coauthor | Scarpa, Aldo | |
dc.contributor.coauthor | Luchini, Claudio | |
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Adsay, Nazmi Volkan | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-12-29T09:38:57Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a recently recognized pancreatic tumor. Here, we aimed to determine its most essential features with the systematic review tool. PubMed, Scopus, and Embase were searched for studies reporting data on pancreatic IOPN. The clinicopathologic, immunohistochemical, and molecular data were extracted and summarized. Then, a comparative analysis of the molecular alterations of IOPN with those of pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm from reference cohorts (including The Cancer Genome Atlas) was conducted. The key findings from 414 IOPNs were as follows: 1) The male-to-female ratio was 1.5:1. Pancreatic head was the most common site (131/237; 55.3%), but a diffuse tumor extension involving more than one pancreatic segment was described in about 1 out of 5 cases (49/237; 20.6%). The mean size was 45.5 mm. An associated invasive carcinoma was present in 50% of cases (168/336). In those cases, most tumors were pT1 or pT2 and pN0 (>80%), and vascular invasion was uncommon (20.6%). Regarding survival, more than 90% of patients were alive after surgical resection. 2) Immunohistochemical and molecular features were as follows. The most commonly expressed mucins were MUC5AC (110/112; 98.2%) and MUC6 (78/84; 92.8%). Compared with pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm, the classic pancreatic drivers KRAS, TP53, CDKN2A, SMAD4, and GNAS were less altered in IOPN (P < .01). Moreover, fusions involving PRKACA or PRKACB gene were detected in all of the 68 cases examined, with PRKACB | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 9 | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | This study is supported by Fondazione Italiana Malattie Pancreas (FIMP-J38D19000690001) ; Italian Ministry of University and Research, through the "Project of significant national interest" (PRIN 2022; code: 2022CMMRWA; CUP: B53D23008010006) ; and Associazione Italiana Ricerca sul Cancro (AIRC IG number: 26343) . Drs O.B. and Z.T. are partly supported by the Cancer Center Sup-port Grant of the National Institutes of Health or National Cancer Institute under award number P30CA008748. M.B. is supported by the Italian Association for Cancer Research fellowship for Italy (28054 and 29829) . | |
dc.description.volume | 37 | |
dc.identifier.doi | 10.1016/j.modpat.2024.100554 | |
dc.identifier.eissn | 1530-0285 | |
dc.identifier.issn | 0893-3952 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85198727300 | |
dc.identifier.uri | https://doi.org/10.1016/j.modpat.2024.100554 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/22865 | |
dc.identifier.wos | 1275728500001 | |
dc.keywords | Intraductal | |
dc.keywords | Intraductal oncocytic papillary | |
dc.keywords | Neoplasm | |
dc.keywords | Oncocytic | |
dc.keywords | Oxyphilic | |
dc.keywords | Pancreatic cancer | |
dc.keywords | PRKACA | |
dc.keywords | PRKACB | |
dc.keywords | Intraductal papillary mucinous | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE INC | |
dc.relation.ispartof | Modern Pathology | |
dc.subject | Pathology | |
dc.title | Comprehensive characterization of intraductal oncocytic papillary neoplasm of the pancreas: a systematic and critical review | |
dc.type | Review | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Adsay, Nazmi Volkan | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | 91bbe15d-017f-446b-b102-ce755523d939 | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | 91bbe15d-017f-446b-b102-ce755523d939 | |
relation.isParentOrgUnitOfPublication | d437580f-9309-4ecb-864a-4af58309d287 | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | d437580f-9309-4ecb-864a-4af58309d287 |
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