Publication:
Comprehensive characterization of intraductal oncocytic papillary neoplasm of the pancreas: a systematic and critical review

dc.contributor.coauthorPaolino, Gaetano
dc.contributor.coauthorBasturk, Olca
dc.contributor.coauthorEsposito, Irene
dc.contributor.coauthorHong, Seung-Mo
dc.contributor.coauthorBrosens, Lodewijk A.
dc.contributor.coauthorTarcan, Zeynep
dc.contributor.coauthorWood, Laura D.
dc.contributor.coauthorGkountakos, Anastasios
dc.contributor.coauthorOmori, Yuko
dc.contributor.coauthorMattiolo, Paola
dc.contributor.coauthorCiulla, Calogero
dc.contributor.coauthorMarchegiani, Giovanni
dc.contributor.coauthorPea, Antonio
dc.contributor.coauthorBevere, Michele
dc.contributor.coauthorDe Robertis, Riccardo
dc.contributor.coauthorD'Onofrio, Mirko
dc.contributor.coauthorSalvia, Roberto
dc.contributor.coauthorCheng, Liang
dc.contributor.coauthorFurukawa, Toru
dc.contributor.coauthorScarpa, Aldo
dc.contributor.coauthorLuchini, Claudio
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAdsay, Nazmi Volkan
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:38:57Z
dc.date.issued2024
dc.description.abstractIntraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a recently recognized pancreatic tumor. Here, we aimed to determine its most essential features with the systematic review tool. PubMed, Scopus, and Embase were searched for studies reporting data on pancreatic IOPN. The clinicopathologic, immunohistochemical, and molecular data were extracted and summarized. Then, a comparative analysis of the molecular alterations of IOPN with those of pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm from reference cohorts (including The Cancer Genome Atlas) was conducted. The key findings from 414 IOPNs were as follows: 1) The male-to-female ratio was 1.5:1. Pancreatic head was the most common site (131/237; 55.3%), but a diffuse tumor extension involving more than one pancreatic segment was described in about 1 out of 5 cases (49/237; 20.6%). The mean size was 45.5 mm. An associated invasive carcinoma was present in 50% of cases (168/336). In those cases, most tumors were pT1 or pT2 and pN0 (>80%), and vascular invasion was uncommon (20.6%). Regarding survival, more than 90% of patients were alive after surgical resection. 2) Immunohistochemical and molecular features were as follows. The most commonly expressed mucins were MUC5AC (110/112; 98.2%) and MUC6 (78/84; 92.8%). Compared with pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm, the classic pancreatic drivers KRAS, TP53, CDKN2A, SMAD4, and GNAS were less altered in IOPN (P < .01). Moreover, fusions involving PRKACA or PRKACB gene were detected in all of the 68 cases examined, with PRKACB
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue9
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis study is supported by Fondazione Italiana Malattie Pancreas (FIMP-J38D19000690001) ; Italian Ministry of University and Research, through the "Project of significant national interest" (PRIN 2022; code: 2022CMMRWA; CUP: B53D23008010006) ; and Associazione Italiana Ricerca sul Cancro (AIRC IG number: 26343) . Drs O.B. and Z.T. are partly supported by the Cancer Center Sup-port Grant of the National Institutes of Health or National Cancer Institute under award number P30CA008748. M.B. is supported by the Italian Association for Cancer Research fellowship for Italy (28054 and 29829) .
dc.description.volume37
dc.identifier.doi10.1016/j.modpat.2024.100554
dc.identifier.eissn1530-0285
dc.identifier.issn0893-3952
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85198727300
dc.identifier.urihttps://doi.org/10.1016/j.modpat.2024.100554
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22865
dc.identifier.wos1275728500001
dc.keywordsIntraductal
dc.keywordsIntraductal oncocytic papillary
dc.keywordsNeoplasm
dc.keywordsOncocytic
dc.keywordsOxyphilic
dc.keywordsPancreatic cancer
dc.keywordsPRKACA
dc.keywordsPRKACB
dc.keywordsIntraductal papillary mucinous
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofModern Pathology
dc.subjectPathology
dc.titleComprehensive characterization of intraductal oncocytic papillary neoplasm of the pancreas: a systematic and critical review
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAdsay, Nazmi Volkan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublication91bbe15d-017f-446b-b102-ce755523d939
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscovery91bbe15d-017f-446b-b102-ce755523d939
relation.isParentOrgUnitOfPublicationd437580f-9309-4ecb-864a-4af58309d287
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relation.isParentOrgUnitOfPublication.latestForDiscoveryd437580f-9309-4ecb-864a-4af58309d287

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