Publication:
Evaluation of renal function in Alzheimer's disease and geriatric patients: Results from a turkish two-center study

dc.contributor.coauthorErbayraktar, Zübeyde
dc.contributor.coauthorEvlice, Ahmet Turan
dc.contributor.coauthorYılmaz, Gökhan
dc.contributor.coauthorYazıcı, Canan
dc.contributor.coauthorYener, Görsev
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorUlusu, Nuriye Nuray
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:32:35Z
dc.date.issued2017
dc.description.abstractBackground: Alzheimer's disease (AD) is a severe multifactorial neurodegenerative proteopathy associated with advanced age. Discrepancies in the renal function of these patients compared to geriatric patients with dementia have rarely been reported. In this study, we aimed to disclose the importance of associated renal changes for the patho genesis of AD. Methods: Patients with AD (n = 107) and geriatric patients with dementia and without dementia (n = 124) (231 patients in total) from Dokuz Eylul and Cukurova University Hospitals were enrolled in the study. We measured serum Na, K, Cl, Ca, BUN, creatinine, total protein levels and MDRD [eGFR] in all groups. Results: From Izmir Center, the first study arm consisted of patients with AD dementia (n = 74), and the second arm included geriatric patients with dementia (n = 79). From Adana, 78 patients were recruited to the study, of which 33 were with AD and 45 were geriatric patients without dementia. When we analyzed comparatively the AD and geriatric dementia patients study arms, a statistically significant difference was observed both in the median age (p < 0.001), as well as in the biochemical parameters from Izmir Center: Na (p < 0.001), K (p < 0.001), Cl (p < 0.05), Ca (p < 0.001), BUN (p < 0.05), creatinine (p < 0.001), total protein (p < 0.001) and MDRD [eGFR] (p < 0.001). How ever, these were not significantly different between AD and geriatric patients without dementia in the Adana group. Conclusions: Our results indicate that renal function is prone to alterations in different age groups of patients with AD. However, there is no conclusive evidence that renal function is one of the risk factors in AD.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher Version
dc.description.volume36
dc.identifier.doi10.1515/jomb-2016-0028
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01264
dc.identifier.issn1452-8258
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85011309620
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1981
dc.identifier.wos393585400008
dc.keywordsAlzheimer's disease
dc.keywordsDementia
dc.keywordsRenal function
dc.language.isoeng
dc.publisherDe Gruyter
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/3324
dc.subjectBiochemistry and molecular biology
dc.titleEvaluation of renal function in Alzheimer's disease and geriatric patients: Results from a turkish two-center study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorUlusu, Nuriye Nuray
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
3324.pdf
Size:
328.06 KB
Format:
Adobe Portable Document Format