Publication:
Importance of parental consanguinity and family history of kidney disease in the Turkish adult chronic kidney disease population: an epidemiologic study

dc.contributor.coauthorCaliskan, Yasar
dc.contributor.coauthorAliyeva, Numune
dc.contributor.coauthorYilmaz, Ozlem
dc.contributor.coauthorCelik, Dilara
dc.contributor.coauthorTurkmen, Aydin
dc.contributor.departmentTIREX (Koç University Transplant Immunology Research Centre of Excellence)
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorDemir, Erol
dc.contributor.kuauthorAkgül, Sebahat Usta
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2025-03-06T21:01:10Z
dc.date.issued2024
dc.description.abstractBackground: This study aims to investigate the frequency of familial relationships and genetic predispositions to kidney disease, analyzing their correlation with chronic kidney disease (CKD). Methods: This observational study included individuals aged 18-70 years (at the time of this study) from October 2009 to 2015. 2576 patients with diverse kidney diseases [mean age: 47 +/- 16 years;1455 men (56.5%)], were compared with 853 healthy individuals with an employed questionnaire. Variables such as siblings, familial kidney disease history, consanguineous marriage, etiology of CKD, age at the time of the study, and diagnosis were compared between groups. Results: Parental consanguinity frequency was similar between groups [n = 174 (6.8%) in the patient group vs. n = 74 (8.7%) in the control group, P = .06]. Kidney disease due to family history was significantly higher in the patient group than in the control group (466 [18.1%] vs. 72 [8.4%], P< .001). Parental consanguinity frequency was notably higher in patients with congenital anomalies of the kidney and urinary tract (CAKUT) (n = 31/234;13.2%) and vesicoureteral reflux (VUR) nephropathy (n = 27/131, 20.5%) compared to controls (8.7%) (P = .036 and P < .001, respectively). Multivariate analysis indicated that predictors of parental consanguinity were kidney disease due to family history (OR: 5.712;95% CI, 4.136-7.890;P < .001), age at kidney disease diagnosis (OR: 0.968;95% CI, 0.957-0.979;P < .001), and kidney disease replacement therapy (OR: 1.441;95% CI, 1.020-2.038;P = .038). Conclusion: The CAKUT and VUR nephropathy risks are increased in consanguineous marriages. Patients with parental consanguinity develop the disease earlier and face a higher risk of kidney failure requiring replacement therapy. Consanguineous marriage might impact the severity of kidney diseases
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.5152/turkjnephrol.2024.22442
dc.identifier.eissn2667-4440
dc.identifier.issue4
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85207634593
dc.identifier.urihttps://doi.org/10.5152/turkjnephrol.2024.22442
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27965
dc.identifier.volume33
dc.identifier.wos1347297900004
dc.keywordsChronic kidney diseases
dc.keywordsConsanguinity
dc.keywordsFamily history
dc.keywordsTurkish population
dc.keywordsVesicoureteral reflux nephropathy
dc.language.isoeng
dc.publisherAVES
dc.relation.ispartofTurkish Journal of Nephrology
dc.subjectUrology and nephrology
dc.titleImportance of parental consanguinity and family history of kidney disease in the Turkish adult chronic kidney disease population: an epidemiologic study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorDemir, Erol
local.contributor.kuauthorAkgül, Sebahat Usta
local.publication.orgunit1Research Center
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2TIREX (Koç University Transplant Immunology Research Centre of Excellence)
local.publication.orgunit2KUH (Koç University Hospital)
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relation.isOrgUnitOfPublication.latestForDiscovery29cd9ca5-6407-4582-92b6-788bc6f33efd
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