Publication:
Meso-2,3-dimercaptosuccinic acid-based macromers for ph-sensitive degradable hydrogelsa

dc.contributor.coauthorGuven, Melek Naz
dc.contributor.coauthorDemirci, Gozde
dc.contributor.coauthorAvci, Duygu
dc.contributor.departmentDepartment of Chemistry
dc.contributor.kuauthorAcar, Havva Funda Yağcı
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.date.accessioned2024-12-29T09:41:06Z
dc.date.issued2023
dc.description.abstractOne way of tailoring the properties of hydrogels is using functional cross-linkers. In this study, four highly watersoluble and degradable carboxylated diacrylate and diacrylamide macromeric cross-linkers were designed as precursors to prepare pH-sensitive and degradable hydrogels. The macromers were synthesized from thiol-Michael addition reaction of meso-2,3dimercaptosuccinic acid (DMSA) with poly(ethylene glycol) diacrylate (PEGDA, M-n = 575 g/mol) or N,N '-methylene bis(acrylamide) (MBA) in the presence of triethyl amine or sodium hydroxide. They were used as cross-linkers in fabrication of 2-hydroxyethyl methacrylate (HEMA)-based hydrogels, whose swelling strongly depended on pH, macromer structure, and hydrogel composition. The degradabilities of the hydrogels were greatly enhanced by increasing the concentration of the cross-linkers. The mechanical properties of the hydrogels can be tuned by tailoring the cross-linking macromer. The hydrogels were proven to have metal chelating ability in the context of Fe3+ ions, and upon this chelation, Young's modulus was also observed to increase significantly. In vitro cytotoxicity evaluations against U-2 OS human bone osteosarcoma epithelial cells and C2C12 mouse myoblast cells showed that the PEGDA functional macromers are not toxic.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue11
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipWe greatly appreciate Prof. Og.uz Okay for his invaluable support in the mechanical studies. The authors would like to acknowledge financial support from Bogazici University Research Fund (19366).
dc.description.volume5
dc.identifier.doi10.1021/acsapm.3c01649
dc.identifier.issn2637-6105
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85176756441
dc.identifier.urihttps://doi.org/10.1021/acsapm.3c01649
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23533
dc.identifier.wos1103623100001
dc.keywordsCross-linker
dc.keywordsHydrogels
dc.keywordsPhotopolymerization
dc.keywordsPh-responsive
dc.keywordsSwelling
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.grantnoBogazici University [19366]
dc.relation.ispartofACS Applied Polymer Materials
dc.subjectMaterials science
dc.subjectMultidisciplinary
dc.subjectPolymer science
dc.titleMeso-2,3-dimercaptosuccinic acid-based macromers for ph-sensitive degradable hydrogelsa
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAcar, Havva Funda Yağcı
local.publication.orgunit1College of Sciences
local.publication.orgunit2Department of Chemistry
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