Publication:
Characteristics of newly diagnosed hepatocellular carcinoma patients across Turkey: prospective multicenter observational 3K registry study

dc.contributor.coauthorAkarca, Ulus Salih
dc.contributor.coauthorÜnsal, Belkıs
dc.contributor.coauthorSezgin, Orhan
dc.contributor.coauthorYalçın, Kendal
dc.contributor.coauthorAkdoğan, Meral
dc.contributor.coauthorGönen, Can
dc.contributor.coauthorGündüz, Feyza
dc.contributor.coauthorÖzenirler, Seren
dc.contributor.coauthorSonsuz, Abdullah
dc.contributor.coauthorDinçer, Dinç
dc.contributor.coauthorTekin, Salim Başol
dc.contributor.coauthorYücel, İdris
dc.contributor.coauthorAkbulut, Hakan
dc.contributor.coauthorAlkım, Canan
dc.contributor.coauthorÖzyılkan, Özgür
dc.contributor.coauthorÇevik, Zeynep Merve
dc.contributor.coauthorİdilman, Ramazan
dc.contributor.coauthor3K Registry Study Group
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBaygül, Arzu Eden
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:11:59Z
dc.date.issued2021
dc.description.abstractAims: to evaluate patient profile for epidemiological and clinicopathological characteristics and potential risk/prognostic factors in newly diagnosed hepatocellular carcinoma (HCC) patients across Turkey. Methods: a total of 547 patients (mean (SD) age 62.6 (10.3) years, 81.9% were males) were included in this registry study. Data on patient characteristics, etiologies of HCC, laboratory values, and tumor characteristics and stages were recorded at study enrollment. Results: HBV infection (68.2%) was the leading etiology, followed by HCV infection (17.2%), HDV infection (5.5%), alcohol (6.4%), and NAFLD (3.5%), as the major etiologies. Considering that 51.6% of the patients had >5 cm HCC, 44% were Child-Pugh B/C and 57% were BCLC B-D, it appears that a significant group of HCC patients were diagnosed at advanced stages. Of 540 patients, 271 (50.2%) were referred or applied with the diagnosis of HCC. Patients with HCC at presentation had larger tumor size (median (min-max) 6.6 (0-30) vs. 4.8 (0-90) cm, P<.001) and more advanced BCLC stage (Stage C-D in 40.8% vs. 26.4%, respectively, P=.005), compared to patients who were diagnosed during follow-up. Conclusions: our findings revealed that HBV infection was the leading etiology and a moderate-to-advanced disease was evident in more than half of patients at the time of diagnosis. HCC patients diagnosed at follow-up had smaller tumor size and earlier BCLC stage.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue12
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipBayer Türk
dc.description.versionPublisher version
dc.description.volume32
dc.identifier.doi10.5152/tjg.2021.201171
dc.identifier.eissn2148-5607
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03373
dc.identifier.issn1300-4948
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85122498900
dc.identifier.urihttps://doi.org/10.5152/tjg.2021.201171
dc.identifier.wos727747700004
dc.keywordsHepatocellular carcinoma
dc.keywordsEpidemiology
dc.keywordsRisk factors
dc.keywordsPrognostic factors
dc.keywordsScreening
dc.keywordsTurkey
dc.language.isoeng
dc.publisherAves
dc.relation.grantnoNA
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10158
dc.subjectGastroenterology and hepatology
dc.titleCharacteristics of newly diagnosed hepatocellular carcinoma patients across Turkey: prospective multicenter observational 3K registry study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBaygül, Arzu Eden
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
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