Publication:
Cytokine response in crimean-congo hemorrhagic fever virus infection

dc.contributor.coauthorEren, Şebnem
dc.contributor.coauthorÇelikbaş, Aysel
dc.contributor.coauthorBaykam, Nurcan
dc.contributor.coauthorDokuzoğuz, Başak
dc.contributor.departmentDepartment of Industrial Engineering
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorCan, Füsun
dc.contributor.kuauthorGönen, Mehmet
dc.contributor.kuauthorŞeref, Ceren
dc.contributor.kuauthorErgönül, Önder
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:11:48Z
dc.date.issued2017
dc.description.abstractWe described the predictive role of cytokines in fatality of Crimean Congo Hemorrhagic Fever Virus (CCHFV) infection by using daily clinical sera samples. Consequent serum samples of the selected patients in different severity groups and healthy controls were examined by using human cytokine 17-plex assay. We included 12 (23%) mild, 30 (58%) moderate, 10 (19%) severe patients, and 10 healthy volunteers. The mean age of the patients was 52 (sd 15), 52% were female. Forty-six patients (88%) received ribavirin. During disease course, the median levels of IL-6, IL-8, IL-10, IL-10/12, IFN-gamma, MCP-1, and MIP-1b were found to be significantly higher among CCHF patients than the healthy controls. Within the first 5 days after onset of disease, among the fatal cases, the median levels of IL-6 and IL-8 were found to be significantly higher than the survived ones (Fig. 3), and MCP-1 was elevated among fatal cases, but statistical significance was not detected. In receiver operating characteristic (ROC) analysis, IL-8 (92%), IL-6 (92%), MCP-1 (79%) were found to be the most significant cytokines in predicting the fatality rates in the early period of the disease (5 days). IL-6 and IL-8 can predict the poor outcome, within the first 5 days of disease course. Elevated IL-6 and IL-8 levels within first 5 days could be used as prognostic markers.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume89
dc.identifier.doi10.1002/jmv.24864
dc.identifier.eissn1096-9071
dc.identifier.issn0146-6615
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85021781864
dc.identifier.urihttps://doi.org/10.1002/jmv.24864
dc.identifier.urihttps://hdl.handle.net/20.500.14288/17549
dc.identifier.wos409231100004
dc.keywordsCrimean-Congo hemorrhagic fever
dc.keywordsCytokine
dc.keywordsRibavirin
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.subjectVirology
dc.titleCytokine response in crimean-congo hemorrhagic fever virus infection
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorErgönül, Mehmet Önder
local.contributor.kuauthorŞeref, Ceren
local.contributor.kuauthorGönen, Mehmet
local.contributor.kuauthorCan, Füsun
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1College of Engineering
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2Department of Industrial Engineering
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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