Publication:
Volumetric arc therapy seems more promising for sparing organs at risk in adjuvant postoperative radiotherapy for pancreatic adenocarcinoma than step-and-shoot intensity-modulated radiotherapy

dc.contributor.coauthorSağlam, Yücel
dc.contributor.coauthorAlpan, Vildan
dc.contributor.coauthorKirsner, Steve
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBölükbaşı, Yasemin
dc.contributor.kuauthorSelek, Uğur
dc.contributor.kuauthorSezen, Duygu
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:28:00Z
dc.date.issued2017
dc.description.abstractOBJECTIVE: The aim of the present study was to determine if volumetric modulated arc therapy (VMAT) provided superior dose distribution than intensity-modulated radiotherapy (step-and-shoot; ssIMRT) based on target volume coverage and organs at risk (OARs) doses in postoperative radiotherapy for pancreatic cancer patients. METHODS: New 4-dimensional computed tomography plans for 10 pancreatic cancer patients were created. The ssIMRT plans had 6 coplanar fields (330-0-30-60-90 degrees) and VMAT plans were generated with 2 268-92 degrees arcs.RESULTS: VMAT plans revealed better overall sparing of right ki dney (volume receiving 15% of prescribed dose [V15]: 28.3% vs 46.9%, p=0.012; V20: 16.1% vs 27.6%, p=0.007; V25: 8.6% vs 15.2%, p=0.005; mean dose 1549 centigray [cGy] vs 1987 cGy, p=0.005). VMAT delivered similar isodose distribution (planning target volume [PTV] mean dose: 5164 vs 5183 cGy, PTV max: 5526 cGy vs 5505 cGy; p=0.541) with significantly fewer monitor units (MU) (MU: 468 vs 527; p=0.032) in comparison with ssIMRT. VMAT was also found to be superior for V30 intestinal dose, but mean dose was similar (1963 cGy vs 2032 cGy; p=0.05). CONCLUSION: VMAT provided more effective protection for bilateral kidneys and small intestine with better OAR doses, as well as for liver, with reduced high-dose volumes in this cohort. This could be investigated as more tolerable concurrent radiochemotherapy treatment with better OAR preservation.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume32
dc.identifier.doi10.5505/tjo.2017.1588
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01279
dc.identifier.issn1300-7467
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85021675444
dc.identifier.urihttps://doi.org/10.5505/tjo.2017.1588
dc.identifier.wos424785500003
dc.keywordsIntensity-modulated radiation therapy
dc.keywordsPancreatic cancer
dc.keywordsVolumetric modulated arc therapy
dc.language.isoeng
dc.publisherTurkish Society for Radiation Oncology
dc.relation.ispartofTürk Onkoloji Dergisi
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/2707
dc.subjectMedicine
dc.subjectOncology
dc.titleVolumetric arc therapy seems more promising for sparing organs at risk in adjuvant postoperative radiotherapy for pancreatic adenocarcinoma than step-and-shoot intensity-modulated radiotherapy
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBölükbaşı, Yasemin
local.contributor.kuauthorSezen, Duygu
local.contributor.kuauthorSelek, Uğur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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