Publication: Volumetric arc therapy seems more promising for sparing organs at risk in adjuvant postoperative radiotherapy for pancreatic adenocarcinoma than step-and-shoot intensity-modulated radiotherapy
dc.contributor.coauthor | Sağlam, Yücel | |
dc.contributor.coauthor | Alpan, Vildan | |
dc.contributor.coauthor | Kirsner, Steve | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Bölükbaşı, Yasemin | |
dc.contributor.kuauthor | Selek, Uğur | |
dc.contributor.kuauthor | Sezen, Duygu | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T12:28:00Z | |
dc.date.issued | 2017 | |
dc.description.abstract | OBJECTIVE: The aim of the present study was to determine if volumetric modulated arc therapy (VMAT) provided superior dose distribution than intensity-modulated radiotherapy (step-and-shoot; ssIMRT) based on target volume coverage and organs at risk (OARs) doses in postoperative radiotherapy for pancreatic cancer patients. METHODS: New 4-dimensional computed tomography plans for 10 pancreatic cancer patients were created. The ssIMRT plans had 6 coplanar fields (330-0-30-60-90 degrees) and VMAT plans were generated with 2 268-92 degrees arcs.RESULTS: VMAT plans revealed better overall sparing of right ki dney (volume receiving 15% of prescribed dose [V15]: 28.3% vs 46.9%, p=0.012; V20: 16.1% vs 27.6%, p=0.007; V25: 8.6% vs 15.2%, p=0.005; mean dose 1549 centigray [cGy] vs 1987 cGy, p=0.005). VMAT delivered similar isodose distribution (planning target volume [PTV] mean dose: 5164 vs 5183 cGy, PTV max: 5526 cGy vs 5505 cGy; p=0.541) with significantly fewer monitor units (MU) (MU: 468 vs 527; p=0.032) in comparison with ssIMRT. VMAT was also found to be superior for V30 intestinal dose, but mean dose was similar (1963 cGy vs 2032 cGy; p=0.05). CONCLUSION: VMAT provided more effective protection for bilateral kidneys and small intestine with better OAR doses, as well as for liver, with reduced high-dose volumes in this cohort. This could be investigated as more tolerable concurrent radiochemotherapy treatment with better OAR preservation. | |
dc.description.fulltext | YES | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.issue | 2 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | National | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | N/A | |
dc.description.version | Publisher version | |
dc.description.volume | 32 | |
dc.identifier.doi | 10.5505/tjo.2017.1588 | |
dc.identifier.embargo | NO | |
dc.identifier.filenameinventoryno | IR01279 | |
dc.identifier.issn | 1300-7467 | |
dc.identifier.quartile | N/A | |
dc.identifier.scopus | 2-s2.0-85021675444 | |
dc.identifier.uri | https://doi.org/10.5505/tjo.2017.1588 | |
dc.identifier.wos | 424785500003 | |
dc.keywords | Intensity-modulated radiation therapy | |
dc.keywords | Pancreatic cancer | |
dc.keywords | Volumetric modulated arc therapy | |
dc.language.iso | eng | |
dc.publisher | Turkish Society for Radiation Oncology | |
dc.relation.ispartof | Türk Onkoloji Dergisi | |
dc.relation.uri | http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/2707 | |
dc.subject | Medicine | |
dc.subject | Oncology | |
dc.title | Volumetric arc therapy seems more promising for sparing organs at risk in adjuvant postoperative radiotherapy for pancreatic adenocarcinoma than step-and-shoot intensity-modulated radiotherapy | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Bölükbaşı, Yasemin | |
local.contributor.kuauthor | Sezen, Duygu | |
local.contributor.kuauthor | Selek, Uğur | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | f91d21f0-6b13-46ce-939a-db68e4c8d2ab | |
relation.isParentOrgUnitOfPublication | 055775c9-9efe-43ec-814f-f6d771fa6dee | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 055775c9-9efe-43ec-814f-f6d771fa6dee |
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