Publication: Clinical pregnancy rates are affected when serum progesterone levels on the day of HCG are> 3.5 ng/ml in patients undergoing IVF with long protocol challenging the previous findings
Program
KU-Authors
KU Authors
Co-Authors
Alper, E.
Yakin, K.
Aksoy, S.
Mercan, R.
Publication Date
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Embargo Status
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Volume Title
Alternative Title
Abstract
Objective: To explore if serum progesterone (P) level on the hCG day has a negative impact on the pregnancy rate in patients undergoing IVF with GnRH agonist long protocol. Design: A non-interventional, retrospective study. Materials and Methods: 2845 IVF cycles performed between 2008-2010 with a GnRH agonist long protocol were included in the study. Pituitary down-regulation was induced with leuprolide acetate. Rec FSH was started on cycle day 3. Ovulation was triggered with rec hCG. E2 and P levels were measured on the hCG day. Decision to proceed with oocyte retrieval was not based on P levels. Results: Progesterone was significantly correlated with E2 level on the day of hCG, and the number of oocytes collected (p<0.01). Patients with P level up to 3.4 ng/mL had comparable whereas the levels ≥ 3.5ng/mL were associated with significantly reduced clinical pregnancy rates.
Source
Publisher
Elsevier Science Inc
Subject
Obstetrics, Gynecology, Reproduction, Biology
Citation
Has Part
Source
Fertility and Sterility
Book Series Title
Edition
DOI
10.1016/j.fertnstert.2013.07.1100